Author: Dr Clemens

Uncategorized Published - 22 November, 2023    By - Dr Clemens
Sociodemographic Disparities in Postoperative Nausea and Vomiting

AUTHORS: Lee, Donaldson C. MD et al  Anesthesia & Analgesia 137(3):p 665-675, September 2023. BACKGROUND: Postoperative nausea and vomiting (PONV) prophylaxis is consistently considered a key indicator of anesthesia care quality. PONV may disproportionately impact disadvantaged patients. The primary objectives of this study were to examine the associations between sociodemographic factors and the incidence of PONV […]

Read More
Uncategorized Published - 22 November, 2023    By - Dr Clemens
Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium

AUTHORS: Dulko, Elzbieta MS et al  Anesthesia & Analgesia 137(1):p 209-220, July 2023. BACKGROUND: We aimed to further validate our previously published animal model for delirium by testing the hypothesis that in aged mice, Anesthesia, Surgery and simulated ICU conditions (ASI) induce sleep fragmentation, electroencephalographic (EEG) slowing, and circadian disarray consistent with intensive care unit (ICU) […]

Read More
Uncategorized Published - 22 November, 2023    By - Dr Clemens
Outpatient Treatment With Gabapentin in Women With Severe Acute Pain After Cesarean Delivery Is Ineffective

AUTHORS: Fowler, Cedar MD, PhD et al  Anesthesia & Analgesia 136(6):p 1122-1132, June 2023. BACKGROUND: Most of the 1.1 million women who deliver by cesarean in the United States each year have an uncomplicated recovery. However, severe pain resistant to standard multimodal therapy within the first days after surgery is associated with an increased risk for […]

Read More
Uncategorized Published - 21 November, 2023    By - Dr Clemens
Maternal Morbidity According to Mode of Delivery Among Pregnant Patients With Pulmonary Hypertension

AUTHORS: Meng, Marie-Louise MD et al Anesthesia & Analgesia May 16, 2023. BACKGROUND: Patients with pulmonary hypertension have a high risk of maternal morbidity and mortality. It is unknown if a trial of labor carries a lower risk of morbidity in these patients compared to a planned cesarean delivery. The objective of this study was […]

Read More
Uncategorized Published - 21 November, 2023    By - Dr Clemens
Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications

AUTHORS: Haller G et al European Journal of Anaesthesiology 34(8):p 492-507, August 2017.  BACKGROUND  Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determine the incidence of surgical patients at increased risk of PPCs, and […]

Read More
Uncategorized Published - 21 November, 2023    By - Dr Clemens
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling

AUTHORS: Chen, Zhao-Rong MM et al  Anesthesia & Analgesia 137(2):p 426-439, August 2023. BACKGROUND: Myocardial infarction is a common perioperative complication, and blood flow restoration causes ischemia/reperfusion injury (IRI). Dexmedetomidine (DEX) pretreatment can protect against cardiac IRI, but the mechanism is still insufficiently understood. METHODS: In vivo, myocardial ischemia/reperfusion (30 minutes/120 minutes) was induced via ligation […]

Read More
Uncategorized Published - 21 November, 2023    By - Dr Clemens
Project SPRUCE: Saving Our Planet by Reducing Carbon Emissions, a Pediatric Anesthesia Sustainability Quality Improvement Initiative

AUTHORS: Hansen, Elizabeth E. MD, PhD et al  Anesthesia & Analgesia 137(1):p 98-107, July 2023. BACKGROUND: Children are particularly vulnerable to adverse health outcomes related to climate change. Inhalational anesthetics are potent greenhouse gasses (GHGs) and contribute significantly to health care–generated emissions. Desflurane and nitrous oxide have very high global warming potentials. Eliminating their use, as […]

Read More
Uncategorized Published - 21 November, 2023    By - Dr Clemens
Management of Muscle Relaxation With Rocuronium and Reversal With Neostigmine or Sugammadex Guided by Quantitative Neuromuscular Monitoring

AUTHORS: Thilen, Stephan R. MD, MS et al  Anesthesia & Analgesia May 12, 2023. BACKGROUND: The optimal pharmacological reversal strategy for neuromuscular blockade remains undefined even in the setting of strong recommendations for quantitative neuromuscular monitoring by several national and international anesthesiology societies. We evaluated a protocol for managing rocuronium blockade and reversal, using quantitative […]

Read More
Uncategorized Published - 20 November, 2023    By - Dr Clemens
Tracheal Narrowing and Its Impact on Anesthesia Care in Patients With Morquio A (Mucopolysaccharidosis Type IVA)

AUTHORS: Theroux, Mary C. MD et al  Anesthesia & Analgesia 137(5):p 1075-1083, November 2023. BACKGROUND:  Recently, tracheal narrowing has been recognized as a significant comorbid condition in patients with Morquio A, also known as mucopolysaccharidosis IVA. We studied a large cohort of patients with Morquio A to describe the extent of their tracheal narrowing and its […]

Read More
Uncategorized Published - 20 November, 2023    By - Dr Clemens
The Timing of Initiating Hydrocortisone and Long-term Mortality in Septic Shock

AUTHORS: Zhang, Luming MD, PhD et al  Anesthesia & Analgesia 137(4):p 850-858, October 2023. BACKGROUND: Previous studies on the association between the timing of corticosteroid administration and mortality in septic shock focused only on short-term mortality and produced conflicting results. We performed a retrospective review of a large administrative database of intensive care unit (ICU) patients […]

Read More