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Authors: Kjaerulff, Isabella et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005780 This prospective mixed-methods study explored the relationship between preoperative psychological distress and postoperative outcomes in older adults undergoing noncardiac, nonneurosurgical procedures. Despite growing recognition that emotional well-being influences recovery, routine distress screening has not yet been integrated into most preoperative assessments. A total of […]
Read MoreAuthors: Persson, Niklas Daniel Åke et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005794 This preclinical imaging study investigated how anesthesia type and systemic hyperosmolality affect the central nervous system (CNS) distribution of intrathecally administered drugs. The researchers examined the pharmacokinetics of a high–molecular weight spinal tracer (technetium-99m–labeled human serum albumin nanocolloid, 66.5 kDa) in female […]
Read MoreEdited by Melissa Warburg Medscape A recent phase 3 study of more than 800 adults, published in Nature, revealed encouraging results for a cannabis extract in treating chronic low back pain, offering new hope for patients seeking nonopioid relief. VER-01, a full-spectrum Cannabis sativa extract, provided sustained pain reduction while also improving sleep quality and physical function, and without requiring […]
Read MoreAuthors: Langer, Sarah et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005785 This meta-analysis of randomized controlled trials compared neonatal outcomes following cesarean delivery performed under regional anesthesia (spinal, epidural, or combined spinal-epidural) versus general anesthesia. Although regional techniques are widely preferred for maternal safety and recovery, their comparative effect on neonatal well-being has remained uncertain. […]
Read MoreAuthors: Padilla, Andrew et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005788 This multicenter retrospective cohort study examined anesthetic practices for cesarean hysterectomy in patients with placenta accreta spectrum (PAS) using data from the Multicenter Perioperative Outcomes Group (MPOG) database. Placenta accreta, increta, and percreta represent progressively invasive forms of abnormal placentation associated with massive hemorrhage […]
Read MoreAuthors: Wilson, Jenna et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005649 This prospective randomized controlled trial evaluated whether intraoperative ketamine reduces acute postsurgical pain in women undergoing breast cancer surgery, while also examining whether baseline temporal summation of pain (a measure of central sensitization) influences ketamine’s efficacy. A total of 225 patients were randomized to […]
Read MoreAuthors: Zhu, Youzhuang et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005800 This randomized controlled trial evaluated whether S-ketamine can reduce postoperative delirium (POD) in elderly patients undergoing total hip or knee arthroplasty under neuraxial anesthesia. The study enrolled 372 patients between November 2023 and October 2024 at a high-volume arthroplasty center with standardized perioperative care […]
Read MoreAuthors: Shen, Fangming et al. Anesthesiology 2025 Oct 14 | DOI: 10.1097/ALN.0000000000005707 This multicenter randomized clinical trial (the AmPRAEC study) evaluated how different anesthesia-maintenance strategies affect postoperative respiratory adverse events (PRAEs) in children undergoing adenotonsillectomy. The investigators enrolled 760 children aged 0–12 years at 12 hospitals in China and randomly allocated them to one of […]
Read MoreHardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]
Read MoreAuthors: Jiang, Xue et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005731 This large longitudinal cohort study investigated whether chronic widespread pain (CWP) contributes to cognitive decline and dementia, as well as potential underlying mechanisms involving brain structure and systemic inflammation. Using data from nearly 190,000 UK Biobank participants followed over 13 years, researchers examined self-reported […]
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