Author: Dr Clemens

Uncategorized Published - 3 February, 2017    By - Dr Clemens
Botox Injections Provide Pain Relief for Knee Osteoarthritis

Intra-articular injections are considered a last resort nonoperative treatment for refractory knee osteoarthritis. Now, patients may achieve a significant reduction in pain for knee OA using a botulinum toxin A injection. Interview with Bahman Jabbari, MD, FAAN The use of botulinum toxin A (BoNT/A) injections for knee osteoarthritis (OA) could be a viable treatment for […]

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Uncategorized Published - 3 February, 2017    By - Dr Clemens
FDA Approves Arymo ER (morphine sulfate), New Abuse-Deterrent Opioid

New extended release morphine tablets are designed to prevent crushing, cutting, or dissolving. The US Food and Drug Administration (FDA) announced the approval of Arymo ER (morphine sulfate) tablets C-II for the management of pain “severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate,” noted a press […]

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Uncategorized Published - 3 February, 2017    By - Dr Clemens
Perioperative Outcomes and Management in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Study from the Pediatric Craniofacial Collaborative Group

Authors: Paul A. Stricker, M.D. et al Anesthesiology 2 2017, Vol.126, 276-287. Background: The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determine perioperative management, outcomes, and complications in […]

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Uncategorized Published - 3 February, 2017    By - Dr Clemens
Intravenous Amisulpride for the Prevention of Postoperative Nausea and Vomiting: Two Concurrent, Randomized, Double-blind, Placebo-controlled Trials

Authors: Tong J. Gan, M.D. et al      Anesthesiology 2 2017, Vol.126, 268-275. Background: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. Methods: Adult inpatients undergoing elective surgery during general anesthesia and having at […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room

Authors: Matthieu Biais, M.D., Ph.D. et al Anesthesiology 2 2017, Vol.126, 260-267. Background: Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Methods: Twenty-eight mechanically ventilated patients with low tidal volume during general […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Arterial Pressure Variation in Elective Noncardiac Surgery: Identifying Reference Distributions and Modifying Factors

Authors: Michael R. Mathis, M.D. et al Anesthesiology 2 2017, Vol.126, 249-259 Background: Assessment of need for intravascular volume resuscitation remains challenging for anesthesiologists. Dynamic waveform indices, including systolic and pulse pressure variation, are demonstrated as reliable measures of fluid responsiveness for mechanically ventilated patients. Despite widespread use, real-world reference distributions for systolic and pulse pressure variation […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Safety of Perioperative Glucocorticoids in Elective Noncardiac Surgery: A Systematic Review and Meta-analysis

Authors: Andrew J. Toner, F.R.C.A. et al       Anesthesiology 2 2017, Vol.126, 234-248. Background: Glucocorticoids are increasingly used perioperatively, principally to prevent nausea and vomiting. Safety concerns focus on the potential for hyperglycemia and increased infection. The authors hypothesized that glucocorticoids predispose to such adverse outcomes in a dose-dependent fashion after elective noncardiac surgery. Methods: The authors conducted […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Impact of Methylprednisolone on Postoperative Quality of Recovery and Delirium in the Steroids in Cardiac Surgery Trial: A Randomized, Double-blind, Placebo-controlled Substudy

Authors: Colin F. Royse, M.B.B.S., M.D., F.A.N.Z.C.A. et al   Anesthesiology 2 2017, Vol.126, 223-233. Background: Inflammation after cardiopulmonary bypass may contribute to postoperative delirium and cognitive dysfunction. The authors evaluated the effect of high-dose methylprednisolone to suppress inflammation on the incidence of delirium and postoperative quality of recovery after cardiac surgery. Methods: Five hundred fifty-five adults from […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Incidence of Connected Consciousness after Tracheal Intubation: A Prospective, International, Multicenter Cohort Study of the Isolated Forearm Technique

Authors: Robert D. Sanders, M.B.B.S., Ph.D., F.R.C.A. et al Anesthesiology 2 2017, Vol.126, 214-222. Background: The isolated forearm technique allows assessment of consciousness of the external world (connected consciousness) through a verbal command to move the hand (of a tourniquet-isolated arm) during intended general anesthesia. Previous isolated forearm technique data suggest that the incidence of connected consciousness […]

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Uncategorized Published - 1 February, 2017    By - Dr Clemens
“To Reverse or Not To Reverse?”: The Answer Is Clear!

Authors: Glenn S. Murphy, M.D. et al Anesthesiology 10 2016, Vol.125, 611-614 BY the late 1980s, it was well recognized that undetected postoperative residual neuromuscular block (PRNB) was a common occurrence in most postanesthesia care units (PACUs).1–4  However, an editorial in 1989 noted that there was little, if any, objective evidence to validate the hypothesis that PRNB […]

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