Author: Dr Clemens

Uncategorized Published - 9 February, 2017    By - Dr Clemens
1 in 3 Adults Diagnosed with Asthma Might Not Have It

Asthma was ruled out in a third of adults who were re-evaluated several years after first being diagnosed with the condition. The findings appear in JAMA. Over 600 randomly selected adults who’d received a physician diagnosis of asthma within the previous 5 years completed symptom questionnaires and underwent spirometry (patients on long-term oral steroids or unable […]

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Uncategorized Published - 9 February, 2017    By - Dr Clemens
Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals

Authors: Rutger van der Schrier, M.D. et al Anesthesiology 3 2017, Vol.126, 534-542. Background: Respiratory depression is a potentially fatal complication of opioid use, which may be exacerbated by simultaneous ethanol intake. In this three-way sequential crossover dose-escalating study, the influence of coadministration of oral oxycodone and intravenous ethanol was assessed on resting ventilation, apneic events and […]

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Uncategorized Published - 9 February, 2017    By - Dr Clemens
Does a Platelet Transfusion Independently Affect Bleeding and Adverse Outcomes in Cardiac Surgery?

Authors: Fabienne M. A. van Hout, M.D. et al Anesthesiology 3 2017, Vol.126, 441-449. Background: Conflicting results have been reported concerning the effect of platelet transfusion on several outcomes. The aim of this study was to assess the independent effect of a single early intraoperative platelet transfusion on bleeding and adverse outcomes in cardiac surgery patients. Methods: For […]

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Uncategorized Published - 9 February, 2017    By - Dr Clemens
Incidence of Connected Consciousness after Tracheal Intubation: A Prospective, International, Multicenter Cohort Study of the Isolated Forearm Technique

Authors: Robert D. Sanders, M.B.B.S., Ph.D., F.R.C.A. et al Anesthesiology 2 2017, Vol.126, 214-222. Background: The isolated forearm technique allows assessment of consciousness of the external world (connected consciousness) through a verbal command to move the hand (of a tourniquet-isolated arm) during intended general anesthesia. Previous isolated forearm technique data suggest that the incidence of connected consciousness […]

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Uncategorized Published - 9 February, 2017    By - Dr Clemens
Effects of Cardiopulmonary Bypass on Renal Perfusion, Filtration, and Oxygenation in Patients Undergoing Cardiac Surgery

Authors: Lukas Lannemyr, M.D. et al Anesthesiology 2 2017, Vol.126, 205-213. Background: Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass. The authors evaluated the effects of normothermic cardiopulmonary bypass on renal blood flow, glomerular filtration rate, renal oxygen consumption, and renal oxygen supply/demand relationship, i.e., renal oxygenation (primary outcome) in patients undergoing cardiac […]

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Uncategorized Published - 8 February, 2017    By - Dr Clemens
Comparison of the Prognostic Significance of Initial Blood Lactate and Base Deficit in Trauma Patients

Authors: Mathieu Raux, M.D., Ph.D. et al      Anesthesiology 3 2017, Vol.126, 522-533. Background: Initial blood lactate and base deficit have been shown to be prognostic biomarkers in trauma, but their respective performances have not been compared. Methods: Blood lactate levels and base deficit were measured at admission in trauma patients in three level 1 trauma centers. This […]

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Uncategorized Published - 8 February, 2017    By - Dr Clemens
Risk Factors and Clinical Outcomes Associated with Perioperative Transfusion-associated Circulatory Overload

Authors: Leanne Clifford, B.M. et al Anesthesiology 3 2017, Vol.126, 409-418 Background: Transfusion-associated circulatory overload remains underappreciated in the perioperative environment. The authors aimed to characterize risk factors for perioperative transfusion-associated circulatory overload and better understand its impact on patient-important outcomes. Methods: In this case–control study, 163 adults undergoing noncardiac surgery who developed perioperative transfusion-associated circulatory overload were […]

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Uncategorized Published - 8 February, 2017    By - Dr Clemens
Complications, Risk Factors, and Staffing Patterns for Noncardiac Surgery in Patients with Left Ventricular Assist Devices

Authors: Michael R. Mathis, M.D. et al      Anesthesiology 3 2017, Vol.126, 450-460. Background: Patients with left ventricular assist devices presenting for noncardiac surgery are increasingly commonplace; however, little is known about their outcomes. Accordingly, the authors sought to determine the frequency of complications, risk factors, and staffing patterns. Methods: The authors performed a retrospective study at their […]

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Uncategorized Published - 8 February, 2017    By - Dr Clemens
Surviving Sepsis Campaign Updates Guidelines for Management of Sepsis and Septic Shock

Authors: Rhodes A et al., Intensive Care Med 2017 Jan 18; This revision of the 2012 guidelines focuses on early management in adults. Sponsoring Organizations: Surviving Sepsis Campaign, Society of Critical Care Medicine, and European Society of Intensive Care Medicine Target Population: Clinicians who care for adult patients with sepsis and septic shock in a hospital setting. Background and […]

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Uncategorized Published - 8 February, 2017    By - Dr Clemens
Cases of Acute Liver Failure Found in Patients Taking Newer Hepatitis C Drugs

The Institute for Safe Medicine Practices reviewed 12 months of FDA data and identified hundreds of cases of acute liver failure in patients taking direct-acting antivirals for hepatitis C. In October, the FDA announced that it was adding a boxed warning to the labels of direct-acting antivirals after identifying 24 cases of hepatitis B reactivation. […]

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