The CDC reported the first death from carbapenem-resistant Enterobacteriaceae (CRE) that was resistant to all antibiotics available in the United States (MMWR Morb Mortal Wkly Rep 2017;66[1]:3). The Nevada woman, who was in her 70s, died from septic shock last September, but the CDC just reported the case, emphasizing that continued surveillance showed that it […]
Read MoreAuthors: Fabienne M. A. van Hout, M.D. et al Anesthesiology 3 2017, Vol.126, 441-449. Background: Conflicting results have been reported concerning the effect of platelet transfusion on several outcomes. The aim of this study was to assess the independent effect of a single early intraoperative platelet transfusion on bleeding and adverse outcomes in cardiac surgery patients. […]
Read MoreAuthors: Ryu Komatsu, M.D. et al Anesthesiology February 23, 2017. Background: Statins may reduce the risk of pulmonary and neurologic complications after cardiac surgery. Methods: The authors acquired data for adults who had coronary artery bypass graft, valve surgery, or combined procedures. The authors matched patients who took statins preoperatively to patients who did not. […]
Read MoreAuthors: Michael R. Mathis, M.D. et al Anesthesiology 3 2017, Vol.126, 450-460. Background: Patients with left ventricular assist devices presenting for noncardiac surgery are increasingly commonplace; however, little is known about their outcomes. Accordingly, the authors sought to determine the frequency of complications, risk factors, and staffing patterns. Methods: The authors performed a retrospective study at their academic tertiary […]
Read MoreIn adult patients undergoing internal fixation of a fracture of the femur, anterior 3-in-1 femoral block and posterior lumbar plexus block have been found to provide comparable analgesia in a recent clinical study. Although the anterior approach resulted in a higher percentage of incomplete blockade, pain scores and opioid requirements did not differ significantly from […]
Read MoreDo individual anesthesiologists directly affect patient outcomes? For years, anesthesiologists have attempted to answer this question empirically. Now, a recent study has concluded that anesthesiologists do affect outcomes, and at a rate similar to that of surgeons. “Despite everything that’s happened with surgical improvement over the years, we still see troubling rates of complications and […]
Read MoreAuthors: Viviane S. Hambrecht-Wiedbusch, Ph.D. et al Background: Promoting arousal by manipulating certain brain regions and/or neurotransmitters has been a recent research focus, with the goal of trying to improve recovery from general anesthesia. The current study tested the hypothesis that a single subanesthetic dose of ketamine during isoflurane anesthesia would increase cholinergic tone in […]
Read MoreEdited by André Sofair, MD, MPH The number of drug overdose deaths in the U.S. has more than doubled since 1999 — from 6.1 to 16 per 100,000 population. Specifically, recent increases have been seen in deaths from heroin and synthetic opioids like fentanyl, according to new CDC data. In 2015, the most recent year […]
Read MoreAuthors: Po-Kuan Chao, Ph.D. et al Anesthesiology February 23, 2017. Background: The authors investigated the pharmacology and signaling pathways of the opioid receptors modulated by compound 1, 1-(2,4-dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one. Methods: In vitro studies of compound 1 were assessed by using a radioligand-binding assay (n = 3), a cyclic adenosine monophosphate assay (n = 3), a β-arrestin […]
Read MoreBy Brian J. Thomas, JD We examine the increasing incidents of distractions in the operating room that potentially threaten patient safety and increase anesthesia providers’ exposure to litigation and other negative consequences. Specifically, distractions from the use of personal electronic devices in the operating room for purposes not related to patient care are reportedly widespread […]
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