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Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Gabapentinoids, increasingly used for chronic low back pain, offer little benefit and carry substantial risks in this setting, finds a systematic review in PLOS Medicine. Researchers examined eight randomized trials in which gabapentin or pregabalin was compared with active or inactive treatments in adults […]
Read MoreEdited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Evidence is limited on the benefits of cannabis use for treating chronic pain and post-traumatic stress disorder, according to two reviews in the Annals of Internal Medicine. The review on chronic pain included 75 studies that examined the potential benefits and harms of cannabis use. There […]
Read MoreThomas L. Schwenk, MD and Allan S. Brett, MD Reviewing Juraschek SP et al., JAMA Intern Med 2017 Jul 24; Blood pressure readings within 1 minute might be more useful in predicting fractures, falls, and other adverse events. According to a 2011 consensus statement, blood pressure (BP) measurement to assess orthostatic hypotension should be done “within 3 minutes […]
Read MoreChristopher B. Oakley, MD Reviewing Bear JJ et al., Neurology 2017 Aug 1; 89:469 A retrospective case analysis finds no association between occipital headache location and intracranial pathology. The International Classification of Headache Disorders (ICHD-3 beta) suggests that headaches localizing to the occipital region in children may be indicative of an intracranial process. This sentiment, however, is not […]
Read MoreAuthors: Nada Sabourdin, M.D. et al Anesthesiology 8 2017, Vol.127, 284-292. Background: Pupillometry has shown promising results for assessing nociception in anesthetized patients. However, its benefits in clinical practice are not demonstrated. The aim of this prospective randomized study was to evaluate the impact of intraoperative pupillometry monitoring on perioperative opioid consumption in major gynecologic surgery. Methods: After […]
Read MoreAuthors: Brad S. Karon, M.D., Ph.D. et al Anesthesiology 9 2017, Vol.127, 466-474. Background: The aim of this study was to evaluate the use of a glucose meter with surgical patients under general anesthesia in the operating room. Methods: Glucose measurements were performed intraoperatively on 368 paired capillary and arterial whole blood samples using a Nova StatStrip (Nova […]
Read MoreAuthors: László Asztalos, M.D. et al Anesthesiology 9 2017, Vol.127, 441-449. Background: Rocuronium-induced neuromuscular block that spontaneously recovered to a train-of-four count of four can be reversed with sugammadex 0.5 or 1.0 mg/kg. We investigated whether these doses of sugammadex can also reverse vecuronium at a similar level of block. Methods: Sixty-five patients were randomly assigned, and 64 were […]
Read MoreAuthors: Karim Asehnoune, M.D., Ph.D. et al Anesthesiology 8 2017, Vol.127, 338-346. Background: Patients with brain injury are at high risk of extubation failure. Methods: We conducted a prospective observational cohort study in four intensive care units of three university hospitals. The aim of the study was to create a score that could predict extubation success in patients […]
Read MoreAuthors: Sandra Funcke, M.D. et al Anesthesiology 8 2017, Vol.127, 272-283. Background: This study compares the analgesic indices Analgesia Nociception Index (heart rate variability), Surgical Pleth Index (photoplethysmography), and pupillary dilatation, to heart rate, mean arterial pressure, and bispectral index, with regard to diagnostic accuracy and prediction probability for nociceptive response. The primary endpoint was the correlation […]
Read MoreAuthors: Maged Y. Argalious, M.D., M.Sc., M.B.A., M.Ed., F.A.S.E. et Anesthesiology 9 2017, Vol.127, 457-465. Background: Whether patients on testosterone replacement therapy undergoing noncardiac surgery have an increased risk of postoperative in-hospital mortality and cardiovascular events remains unknown. We therefore sought to identify the impact of testosterone replacement on the incidence of a composite of postoperative in-hospital […]
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