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Anesthesiology Published - 7 April, 2026    By - Dr Clemens
Evaluating the Statistical Robustness of Randomized Controlled Trials of Spinal Cord Stimulation for Pain through the Use of Fragility Index

Authors: Hussain N et al. Anesthesiology 144(4):898–912, April 2026 Summary:This study evaluates the strength of evidence supporting spinal cord stimulation (SCS) for chronic pain by applying the fragility index—a statistical measure that assesses how many outcome changes would be needed to overturn a trial’s results. Unlike traditional P values, the fragility index provides insight into […]

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Anesthesiology Published - 7 April, 2026    By - Dr Clemens
Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures

Authors: Jung S et al. Anesthesiology 144(4):871–885, April 2026 Summary:This experimental study investigates a key mechanism behind anesthetic-induced neurotoxicity, focusing on how Isoflurane disrupts calcium regulation in neurons. The authors specifically examined whether impaired calcium removal—rather than increased calcium entry—drives neuronal injury. Using mouse neuronal cultures, the study demonstrated that isoflurane significantly prolongs the time […]

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Anesthesiology Published - 7 April, 2026    By - Dr Clemens
Role of Dorsomedial Periaqueductal Gray Glutamatergic Neurons in Promoting Arousal under Multiple General Anesthetics in Mice

Authors: Tong L et al. Anesthesiology 144(4):853–870, April 2026 Summary:This mechanistic study investigates the role of glutamatergic neurons in the dorsomedial periaqueductal gray (dmPAG) as a potential common neural pathway regulating anesthesia and emergence. The periaqueductal gray has long been recognized for its role in pain and defensive behaviors, but its contribution to anesthesia–arousal transitions […]

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Anesthesiology Published - 7 April, 2026    By - Dr Clemens
Returning to Anesthesia After Burnout, Pain Management, ICU med or administrative job? We Built a Path Back

Burnout or time away in pain, ICU, or administration doesn’t erase your anesthesia training—it just requires a structured path back. For many physicians, it simply means you stepped away to regroup. We work with anesthesiologists every day who want to return to clinical anesthesia after time away in: administration or leadership roles pain medicine critical […]

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Anesthesiology Published - 7 April, 2026    By - Dr Clemens
BEST Independent CRNA Opportunity – Savannah, TN just increased salary $15,000

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]

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