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Uncategorized Published - 15 September, 2016    By - Dr Clemens
Dexmedetomidine Lowered the Incidence of Postoperative Delirium

Authors: Su X et al., Lancet 2016 Aug 16; But this practice probably is unnecessary in extubated patients. In a recent placebo-controlled study, delirium resolved more quickly in delirious patients in the intensive care unit (ICU) who received dexmedetomidine (NEJM JW Gen Med May 15 2016 and JAMA 2016; 315:1455). However, whether this finding was due to a direct effect […]

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Uncategorized Published - 15 September, 2016    By - Dr Clemens
Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity

Authors: Yifei Jiang, M.D., Ph.D. et al Anesthesiology published on September 22, 2016 Background: Exposure to isoflurane increases apoptosis among postnatally generated hippocampal dentate granule cells. These neurons play important roles in cognition and behavior, so their permanent loss could explain deficits after surgical procedures. Methods: To determine whether developmental anesthesia exposure leads to persistent deficits in granule […]

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Uncategorized Published - 15 September, 2016    By - Dr Clemens
Are Opioid-tolerant Patients Resistant to Local Anesthetic Nerve Blockade?: We Need More Information

Authors: Timothy J. Brennan, M.D., Ph.D. et al THE management of acute pain in the opioid-tolerant patients is an important topic in perioperative medicine. In this issue of Anesthesiology, Liu and Gold1 demonstrate that morphine administration that induces morphine tolerance in rats produces resistance to lidocaine-induced nerve blockade ex vivo. Acute pain management can be quite challenging […]

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Uncategorized Published - 15 September, 2016    By - Dr Clemens
Avoiding Repeated Attempts at Tracheal Intubation: Can Videolaryngoscopes Be the Answer?

Authors: Takashi Asai, M.D., Ph.D. Anesthesiology 10 2016, Vol.125, 615-617. REPEATED attempts at tracheal intubation increase the incidence of airway obstruction, leading to serious airway complications.1,2  Therefore, major guidelines for difficult airway management unanimously recommend avoiding repeated attempts at tracheal intubation.3–5  Much effort has been made to reduce the incidence of difficult intubation with a conventional Macintosh or […]

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Uncategorized Published - 15 September, 2016    By - Dr Clemens
Reference Values for Noninvasive Blood Pressure in Children during Anesthesia: A Multicentered Retrospective Observational Cohort Study

Authors: Jurgen C. de Graaff, M.D., Ph.D. et al Anesthesiology Newly Published on September 8, 2016 Background: Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. Methods: In […]

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