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Uncategorized Published - 3 February, 2017    By - Dr Clemens
FDA Approves Arymo ER (morphine sulfate), New Abuse-Deterrent Opioid

New extended release morphine tablets are designed to prevent crushing, cutting, or dissolving. The US Food and Drug Administration (FDA) announced the approval of Arymo ER (morphine sulfate) tablets C-II for the management of pain “severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate,” noted a press […]

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Uncategorized Published - 3 February, 2017    By - Dr Clemens
Perioperative Outcomes and Management in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Study from the Pediatric Craniofacial Collaborative Group

Authors: Paul A. Stricker, M.D. et al Anesthesiology 2 2017, Vol.126, 276-287. Background: The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determine perioperative management, outcomes, and complications in […]

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Uncategorized Published - 3 February, 2017    By - Dr Clemens
Intravenous Amisulpride for the Prevention of Postoperative Nausea and Vomiting: Two Concurrent, Randomized, Double-blind, Placebo-controlled Trials

Authors: Tong J. Gan, M.D. et al      Anesthesiology 2 2017, Vol.126, 268-275. Background: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. Methods: Adult inpatients undergoing elective surgery during general anesthesia and having at […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room

Authors: Matthieu Biais, M.D., Ph.D. et al Anesthesiology 2 2017, Vol.126, 260-267. Background: Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Methods: Twenty-eight mechanically ventilated patients with low tidal volume during general […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Arterial Pressure Variation in Elective Noncardiac Surgery: Identifying Reference Distributions and Modifying Factors

Authors: Michael R. Mathis, M.D. et al Anesthesiology 2 2017, Vol.126, 249-259 Background: Assessment of need for intravascular volume resuscitation remains challenging for anesthesiologists. Dynamic waveform indices, including systolic and pulse pressure variation, are demonstrated as reliable measures of fluid responsiveness for mechanically ventilated patients. Despite widespread use, real-world reference distributions for systolic and pulse pressure variation […]

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