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Authors: Viviane S. Hambrecht-Wiedbusch, Ph.D. et al Background: Promoting arousal by manipulating certain brain regions and/or neurotransmitters has been a recent research focus, with the goal of trying to improve recovery from general anesthesia. The current study tested the hypothesis that a single subanesthetic dose of ketamine during isoflurane anesthesia would increase cholinergic tone in […]
Read MoreEdited by André Sofair, MD, MPH The number of drug overdose deaths in the U.S. has more than doubled since 1999 — from 6.1 to 16 per 100,000 population. Specifically, recent increases have been seen in deaths from heroin and synthetic opioids like fentanyl, according to new CDC data. In 2015, the most recent year […]
Read MoreAuthors: Po-Kuan Chao, Ph.D. et al Anesthesiology February 23, 2017. Background: The authors investigated the pharmacology and signaling pathways of the opioid receptors modulated by compound 1, 1-(2,4-dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one. Methods: In vitro studies of compound 1 were assessed by using a radioligand-binding assay (n = 3), a cyclic adenosine monophosphate assay (n = 3), a β-arrestin […]
Read MoreBy Brian J. Thomas, JD We examine the increasing incidents of distractions in the operating room that potentially threaten patient safety and increase anesthesia providers’ exposure to litigation and other negative consequences. Specifically, distractions from the use of personal electronic devices in the operating room for purposes not related to patient care are reportedly widespread […]
Read Moreby Maria Magro, PhD, CRNA, and Matthew Weinger, MD Distractions in the perioperative work environment can be attributed to many sources. When considering distractions, one must distinguish those that are externally imposed from those that are internally motivated. Many of the externally imposed distractions may be considered interruptions from the environment, other team members, or […]
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