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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Patients Undergoing Cesarean Delivery After Exposure to Oxytocin During Labor Require Higher Postpartum Oxytocin Doses

AUTHORS: Foley, Amanda MD et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 920–924 BACKGROUND: Experts recommend postpartum oxytocin to prevent uterine atony and hemorrhage, but oxytocin may be associated with dose-dependent adverse effects, and the correct dose of postpartum oxytocin has yet to be determined. The effective dose in 90% […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Intraoperative Esmolol as an Adjunct for Perioperative Opioid and Postoperative Pain Reduction: A Systematic Review, Meta-analysis, and Meta-regression

AUTHORS: Gelineau, Amanda M. MD et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 1035–1049 BACKGROUND: Esmolol is an ultrashort β-1 receptor antagonist. Recent studies suggest a role for esmolol in pain response modulation. The authors performed a meta-analysis to determine if the intraoperative use of esmolol reduces opioid consumption or […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
The Effect of Adductor Canal Block on Knee Extensor Muscle Strength 6 Weeks After Total Knee Arthroplasty: A Randomized, Controlled Trial

AUTHORS: Rousseau-Saine, Nicolas MD et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 1019–1027 BACKGROUND: Total knee arthroplasty (TKA) reduces knee extensor muscle strength (KES) in the operated limb for several months after the surgery. Immediately after TKA, compared to either inguinal femoral nerve block or placebo, adductor canal block (ACB) […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Targeted Temperature Management After Cardiac Arrest: Systematic Review and Meta-analyses

AUTHORS: Kalra, Rajat MBChB et al Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 867–875 BACKGROUND: Targeted temperature management (TTM) with therapeutic hypothermia is an integral component of postarrest care for survivors. However, recent randomized controlled trials (RCTs) have failed to demonstrate the benefit of TTM on clinical outcomes. We sought to […]

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Uncategorized Published - 14 March, 2018    By - Dr Clemens
Novel Opioid Has Faster Onset of Pain Relief, Leads to Fewer Adverse Events

Now in Phase III Trials: An investigational agent designed to improve conventional opioid pharmacology has demonstrated efficacy and safety, as well as faster onset of action, in a pair of pivotal trials. Compared with placebo, patients receiving IV oliceridine (Olinvo, Trevena), a G protein-biased ligand (GPBL) at the mu-opioid receptor, experienced superior relief following bunionectomy or abdominoplasty. Oliceridine also showed favorable […]

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