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The Food and Drug Administration (FDA) has approved Apadaz (benzhydrocodone and acetaminophen; KemPharm) for the short-term (≤14 days) management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Apadaz is an immediate-release combination of benzhydrocodone, a prodrug of hydrocodone, and acetaminophen (APAP). Benzhydrocodone is chemically inert, however, once ingested, […]
Read MoreRecommendations for the perioperative use of buprenorphine during interventional pain procedures, including best practices for perioperative tapering of the drug, were recently published in Pain Physician. The researchers based their buprenorphine recommendations on an analysis of 12 studies in the literature researching buprenorphine. The recommendations include suggestions for tapering or continuing use of the drug in the […]
Read MoreThe American Society of Anesthesiologists (ASA) has offered recommendations for Congress to address the opioid epidemic through the Centers for Medicare & Medicaid Services programs. The recommendations include increasing funding for research, adding coverage for nonopioid therapies, and providing congressional support for educational programs for perioperative opioid-sparing practices. “With a unique understanding of the intricacies […]
Read MoreNaldemedine, a peripherally acting µ-opioid receptor antagonist, was found to be safe and effective for increasing bowel movement frequency and improving quality of life in patients with chronic non-cancer pain and opioid-induced constipation (OIC), in a randomized placebo-controlled phase 3 trial published in Pain. In addition, naldemedine was not found to affect opioid analgesia or to […]
Read MoreIt might not just be old age causing forgetfulness. A new study, published in the journal Anaesthesia, found associations with decreased cognitive function and time under general anesthesia or neuraxial blockade. This observational study followed nearly a thousand middle-aged patients at the Wisconsin Registry for Alzheimer’s Prevention, testing the memory and executive function of participants on […]
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