How fish oil might reduce inflammation

The trial tested three doses of enriched fish oil supplement against the placebo. The researchers took samples of the participants’ blood to test.

Each participant gave five samples over 24 hours — at baseline and then 2, 4, 6, and 24 hours after taking their dose of supplement or placebo.

The researchers found that taking the enriched fish oil supplement raised blood levels of SPMs. The results showed a “time and dose-dependent” increase in circulating blood levels of SPMs.

The tests also revealed that supplementation led to a dose-dependent increase in immune cell attacks against bacteria and a decrease in cell activity that promotes blood clotting.

Inflammation is a defense response by the immune system that is essential to health. Various factors can trigger the response, including damaged cells, toxins, and pathogens such as bacteria.

Some of the immune cells that are active during inflammation can also damage tissue, so it is important, once the threat is over, for inflammation to subside to allow healing. Putting a stop to inflammation is where anti-inflammatory agents, such as SPMs, have a role.

However, if inflammation persists and becomes chronic, then, instead of protecting health, it undermines it. Studies have linked inflammation to heart disease, rheumatoid arthritis, and other serious health conditions.

Although it remains unclear whether those molecules reduce cardiovascular disease, a press release on the study notes that they do “supercharge macrophages, specialized cells that destroy bacteria and eliminate dead cells,” as well as making “platelets less sticky, potentially reducing the formation of blood clots.”

Research has also shown the molecules to play a role in tissue regeneration. As Prof. Dalli notes, “These molecules have multiple targets.”

An earlier 2019 study in NEJM showed that a prescription formula containing eicosapentaenoic acid (EPA) could reduce heart attacks and strokes — and deaths relating to these events — in people who are at high risk of cardiovascular disease or already have it. EPA is an omega-3 fatty acid that is present in fish oil.

However, Dr. Deepak L. Bhatt, who is a cardiologist at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, both in Boston, MA, and who led that study, says that there is no reliable evidence that over-the-counter supplements can have the same effect.

In the United States, federal regulators have approved two formulations: one containing EPA and a second that combines EPA with another omega-3 fatty acid called docosahexaenoic acid (DHA).

The American Heart Association (AHA) recently issued a scientific advisory that cautions consumers to avoid unregulated omega-3 supplements.

An earlier AHA advisory had stated that while such supplements may slightly lessen the risk of death following a heart attack or heart failure, there is no evidence that they prevent heart disease in the first place.

Prof. Dalli says that there is a need for further studies to establish whether people over the age of 45 years would experience the same results from enriched fish oil supplements that they saw in the younger volunteers.

Compared with healthy people, those living with chronic inflammation have lower levels of SPMs, he remarks, noting that the enzymes that produce them do not work as well in these individuals.

He suggests that this is the kind of information that developers will need to consider when formulating supplements for treating disease. It will also be important to check that the body is breaking down the supplements into protective molecules.

“We’re still far away from having the magic formula. Each person will need a specific formulation or at least a specific dosing, and that’s something we need to learn more about.”

Prof. Jesmond Dalli