Author: Li X et al.
BMC Anesthesiology 25:391. doi:10.1186/s12871-025-02989-9
This retrospective study analyzed 86 elderly intensive care unit patients with sepsis to evaluate whether platelet parameters and hemorheological indicators predict mortality and multiple organ failure. Patients were divided into survival (n=58) and death (n=28) groups.
Higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, Sequential Organ Failure Assessment (SOFA) scores, mean platelet volume (MPV), plasma viscosity, Equation K value of erythrocyte sedimentation rate (ESR), and red cell distribution width (RDW) were associated with mortality. SOFA scores correlated positively with MPV, plasma viscosity, Equation K value of ESR, and RDW. Logistic regression identified these variables, along with APACHE II score, as independent risk factors for death.
Receiver operating characteristic analysis showed that combining MPV, plasma viscosity, Equation K value of ESR, and RDW improved predictive accuracy (AUC=0.879) compared with individual markers. The authors suggest these measures could provide a simpler, rapid adjunct to traditional scoring systems for mortality risk assessment in elderly sepsis patients, though prospective multicenter validation is needed.
References
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Li X, He Y, Lu X, et al. BMC Anesthesiol. 2025;25:391. doi:10.1186/s12871-025-02989-9.
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