The haemostasis traffic light: a pragmatic tool for bleeding management

Anaethesia Perioperative Medicine, Critical Care and Pain
Major bleeding is a critical scenario which can quickly develop into a crisis, thereby compromising patient safety. Controversy still exists regarding the best approach for haemostatic management with different initial coagulation resuscitation strategies receiving the same level of recommendation 12. From a logistical point of view, the availability of certain resources does not necessarily imply their timely application. Turnaround times of local diagnostic and therapeutic resources are often neglected when drafting coagulation management protocols. Such uncertainties may impede the much needed shared mental model by the medical team resulting in great variability during crisis management negatively impacting treatment delivery 3. In this context, checklists and cognitive aids have been found to be useful in assembling the team under one conceptual umbrella. Hence, the integration of logistic and human factors is fundamental to translate knowledge into actions and benefit both patients and health professionals 4.

In order to simplify the initial assessment and management of a bleeding situation, we have developed the ‘haemostasis traffic light’ (Fig. 1). Firstly, we obtained our actual turnaround times over 4 months which enabled us to see which diagnostic and therapeutic resources are readily available at different time‐points during the first 45 min from the onset of bleeding 58. Subsequently, we developed an early clinical classification system including haemodynamic stability, requirement for and response to vasopressors and fluids, and the surgical possibility to limit bleeding over time. This aligns with the recommendation that during the initial evaluation, the physician should clinically assess the extent of the haemorrhage using a combination of patient physiology, the anatomic pattern of injury and its mechanism, along with the patient’s response to initial resuscitation manoeuvres 2. The resulting therapeutic approach we have developed targets clot stability, clot strength and thrombin generation according to the pathophysiology of the developing coagulopathy and the severity of the scenario.

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The haemostasis traffic light cognitive tool. The criteria classify the clinical situation according to the severity in each of the lights (CODE). The next column indicates what priorities should be primarily addressed while treating the patient from the pathophysiological aspect. In the STRATEGY column, we propose combined therapeutic interventions (packs) to timely attend these haemostatic priorities. Finally, the ALTERNATIVES column provides individual therapeutic options to the corresponding strategy in case one or several of them are not available. TXA, tranexamic acid; FC, fibrinogen concentrate; 4‐ PCC, 4‐factor prothrombin complex concentrate; VET, viscoelastic testing; POC, point of care; Cryo, cryoprecipitate; pRBCs, packed red blood cells; T, temperature; Cai, ionised calcium; Hb, haemoglobin; BD, base deficit.

When facing a red‐light situation, we suggest treating the patient immediately and drawing blood samples for viscoelastic testing to assess the initial intervention. The idea is to stop the progression of coagulopathy during severe bleeding by addressing the most frequently altered aspects of haemostasis in shock: hyperfibrinolysis, decreased clot strength and slowed thrombin generation 9. Also, when treating hemodynamic shock, one should anticipate the inevitable iatrogenic haemodilution. This is due to the aggressive volume therapy which is often needed to maintain adequate perfusion with ‘factor‐free’ fluids such as crystalloids and colloids and may interfere with thrombin generation and fibrinogen functionality. In a yellow‐light situation, the priority is to assure clot stability and strength and all further treatment should be guided by point of care measurements. Finally, in the green‐light situation, no blind interventions are needed, and a complete targeted strategy should be implemented from the start.

The triple‐colour code of a traffic light is familiar to most people and helps to prioritise diagnostic and therapeutic interventions in bleeding patients. Using an intuitive and didactic tool facilitates the process of gaining situational awareness, improves communication, raises diagnostic confidence and reduces stress and work‐load within the healthcare team 10. Another advantage of the traffic light design lies in its dynamic nature, allowing us to evaluate and re‐evaluate the clinical situation, switching into a different light if needed (‘switch and re‐assess’). One could easily argue that this proposal represents a setback in the struggle for the individualisation of medical therapies. However, we feel that the simplification of complex processes has been long‐awaited by those at the front line of bleeding and coagulation crisis management.

The haemostasis traffic light brings the possibility to narrow the gap between the bleeding experts and the bleeding caregivers at the sharp end of patient care, by providing comprehensive and pragmatic support in demanding situations. It could also serve as an educational tool during anaesthesia crisis resource management courses and formal training. Incorporating local‐specific logistical considerations, evidence‐based best‐practice treatment recommendations and human factor aspects, it aims to allow timely interventions through a standardised and optimised utilisation of both diagnostic and therapeutic resources. Finally, proper studies are needed to validate the success of this tool in the clinical setting.

References

1 Winearls JReade MMiles H, et al. Targeted coagulation management in severe trauma: the controversies and the evidenceAnesthesia and Analgesia 2016123910– 24.

2 Spahn DRBouillon BCerny V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth editionCritical Care 20192398.

4 Jones CPLFawker‐Corbett JGroom PMorton BLister CMercer SJHuman factors in preventing complications in anaesthesia: a systematic reviewAnaesthesia 201873Suppl. 1): 12– 24.

6 Haas TSpielmann NMauch J, et al. Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgeryBritish Journal of Anaesthesia 201210836– 41.

7 Mileo FGLopez MSKataife ED, et al. Rotational thromboelastometry (ROTEM delta) turnaround times in a third level medical center: a cross‐sectional study in a retrospective cohortHematología – Sociedad Argentina de Hematología – XIII Congreso Grupo CAHT 201822332.

8 Mileo FGKataife EDAdrover AGarcía FGMartinuzzo MELopez MSHaemostasis traffic light: the development of a bleeding management tool based on turnaround times and therapeutic resources in a third level medical centerEuropean Journal of Anaesthesiology – Euroanaesthesia 2019 Abstract Book 201936284.

9 Johansson PIStensballe JOstrowski SRShock induced endotheliopathy (SHINE) in acute critical illness ‐ a unifying pathophysiologic mechanismCritical Care 20172125.

10 MacDougall‐Davis SRKettley LCook TMThe “go‐between” study: a simulation study comparing the “Traffic Lights” and “SBAR” tools as a means of communication between anaesthetic staffAnaesthesia 201671764– 72.

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