Authors: Ganguly S, Haque A, Ram B, et al.
Cureus 17(7): e89140. doi:10.7759/cureus.89140
This prospective randomized study compared the effects of sevoflurane and isoflurane on postoperative cognitive dysfunction (POCD) following laparoscopic cholecystectomy. Conducted at the Rajendra Institute of Medical Sciences, India, the study enrolled 90 patients equally divided into sevoflurane and isoflurane groups. The primary endpoint was postoperative cognitive performance assessed using the Montreal Cognitive Assessment (MoCA) score at various intervals post-surgery.
Results showed no significant difference in MoCA scores between the groups at six hours post-anesthesia. However, at 24 hours, a statistically significant difference emerged (p=0.04), favoring better cognitive outcomes in the sevoflurane group. Both groups experienced a decrease in MoCA scores at one and six hours postoperatively, indicating early transient cognitive decline. Additionally, common adverse effects such as nausea, vomiting, and shivering were observed to diminish over time in both groups.
The findings suggest that while both anesthetic agents are associated with early postoperative cognitive decline, sevoflurane may offer a modest cognitive advantage at 24 hours post-surgery compared to isoflurane.
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