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AUTHORS: Turan, Alparslan, MD et al Anesthesia & Analgesia: March 2019 – Volume 128 – Issue 3 – p 494–501 BACKGROUND: Neuraxial anesthesia improves components of the Virchow’s triad (hypercoagulability, venous stasis, and endothelial injury) which are key pathogenic contributors to venous thrombosis in surgical patients. However, whether neuraxial anesthesia reduces the incidence of venous thromboembolism […]
Read MoreAUTHORS: Rogge, Dorothea E., MD et al Anesthesia & Analgesia: March 2019 – Volume 128 – Issue 3 – p 477–483 BACKGROUND: Continuous monitoring of arterial pressure is important in severely obese patients who are at particular risk for cardiovascular complications. Innovative technologies for continuous noninvasive arterial pressure monitoring are now available. In this study, we […]
Read MoreAUTHORS: Sabourdin, Nada, MD et al Anesthesia & Analgesia: March 2019 – Volume 128 – Issue 3 – p 467–474 BACKGROUND: The pupillary pain index (PPI) is a novel pupillometric index, designed to assess intraoperative analgesia. It is based on the evaluation of the pupillary response to electrical stimuli of increasing intensity. It ranges from 1 […]
Read MoreAUTHORS: Yung, Eric M., BHSc, MD (Cand) et al Anesthesia & Analgesia: March 2019 – Volume 128 – Issue 3 – p 426–437 BACKGROUND: Local infiltration analgesia offers effective postoperative analgesia after knee arthroplasty, but the role of its counterpart, local instillation analgesia (LIA), in anterior cruciate ligament reconstruction (ACLR) is unclear. This systematic review and […]
Read MoreAuthors: Connolly SJ et al. N Engl J Med 2019 Feb 7 An uncontrolled study shows rapid efficacy in reducing elevated anti-FXa inhibitor levels. The anticoagulant activity of oral direct factor Xa (FXa) inhibitors and low-molecular-weight heparins such as enoxaparin can be reversed by andexanet, a modified, recombinant inactive form of FXa. Andexanet was recently approved […]
Read MoreAuthors: Daniel Golkowski, M.D. et al Anesthesiology 6 2019, Vol.130, 898-911. doi:10.1097/ALN.0000000000002704 Editor’s Perspective:What We Already Know about This Topic: The extent to which alterations within specific brain networks impairs communication among networks remains unknown What This Article Tells Us That Is New: In a volunteer functional magnetic resonance study, general anesthesia reduced activity within and […]
Read MoreAuthors: Phillip E. Vlisides, M.D. et al Anesthesiology 6 2019, Vol.130, 885-897. Editor’s Perspective:What We Already Know about This Topic: Animal data, along with recent human observations (in this issue of Anesthesiology*), suggest that cortical oscillations and connectivity shift dynamically during what appears to be stable general anesthesia Clinical evidence in the perioperative setting to support […]
Read MoreAuthors: Leon Vorobeichik, M.D. et al Anesthesiology 6 2019, Vol.130, 1037-1038. After an uneventful total knee arthroplasty under spinal anesthesia and ultrasound-guided continuous adductor canal block, the absence of distal pulses was noted in the operative leg. An arterial duplex scan (top image, panel A) demonstrated a femoral artery dissection flap (thin arrow) with a false […]
Read MoreAuthors: Viviane G. Nasr, M.D. et al Anesthesiology 6 2019, Vol.130, 971-980. Editor’s Perspective:What We Already Know about This Topic: Risk stratification models to predict perioperative mortality in pediatric surgical populations are based on patient comorbidities, but do not take into consideration the intrinsic risk of the surgical procedures. What This Article Tells Us That Is […]
Read MoreAuthor: David Holtzman Anesthesiology News Researchers might have found a new link to Clostridioides difficile (formerly Clostridium difficile):the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Antibiotics, which disturb the gut microbiome, have always taken the blame for this highly prevalent nosocomial infection. But new findings in an animal model provide evidence for the NSAID connection, while describing a potential […]
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