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Uncategorized Published - 25 July, 2019    By - Dr Clemens
Effects of Anticholinesterase Reversal Under General Anesthesia on Postoperative Cardiovascular Complications

AUTHORS: Shaydenfish, Denys Cand Med et al Anesthesia & Analgesia: March 2019 BACKGROUND: The anticholinesterase neostigmine and the muscarinic inhibitor glycopyrrolate are frequently coadministered for the reversal of neuromuscular blockade. This practice can precipitate severe bradycardia or tachycardia, but whether it affects the incidence of cardiovascular complications remains unclear. We hypothesized that anticholinesterase reversal with neostigmine and […]

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Uncategorized Published - 25 July, 2019    By - Dr Clemens
Prospective Investigation of the Operating Room Time-Out Process

AUTHORS: Freundlich, Robert E. MD, MS et al Anesthesia & Analgesia: March 2019 BACKGROUND: Although the surgical pause or time-out is a required part of most hospitals’ standard operating procedures, little is known about the quality of execution of the time-out in routine clinical practice. An interactive electronic time-out was implemented to increase surgical team compliance with […]

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Uncategorized Published - 24 July, 2019    By - Dr Clemens
Review on Rubinstein-Taybi Syndrome

Rarities With Anesthetic Implications Elizabeth A.M. Frost, MD Professor of Anesthesiology Mount Sinai Medical Center New York, New York Anesthesiology News Rubinstein-Taybi Syndrome What Is It? First described by Michail et al in 19571 as broad thumb–hallux disorder, the syndrome was named for Drs. Rubenstein and Taybi who published a case series of seven cases in […]

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Uncategorized Published - 24 July, 2019    By - Dr Clemens
Pain Management for Ambulatory Arthroscopic Anterior Cruciate Ligament Reconstruction: Evidence-Based Recommendations From the Society for Ambulatory Anesthesia

AUTHORS: Abdallah, Faraj W. MD et al Anesthesia & Analgesia: April 2019 – Volume 128 – Issue 4 – p 631-640 Ambulatory arthroscopic anterior cruciate ligament reconstruction is associated with moderate pain, even when nonopioid oral analgesics such as acetaminophen and nonsteroidal anti-inflammatory drugs are used. Regional analgesia can supplement nonopioid oral analgesics and reduce postoperative […]

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Uncategorized Published - 24 July, 2019    By - Dr Clemens
Cardiac Risk of Noncardiac Surgery After Percutaneous Coronary Intervention With Second-Generation Drug-Eluting Stents

AUTHORS: Smith, Bradford B. MD et al Anesthesia & Analgesia: April 2019 – Volume 128 – Issue 4 – p 621-628 BACKGROUND: Noncardiac surgery (NCS) following percutaneous coronary intervention (PCI) with stenting is sometimes associated with major adverse cardiac events (MACEs). Second-generation drug-eluting stents (DES) were developed to decrease the incidence of MACE seen with bare […]

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Uncategorized Published - 24 July, 2019    By - Dr Clemens
Association of Testosterone Replacement Therapy and the Incidence of a Composite of Postoperative In-Hospital Mortality and Cardiovascular Events in Men Undergoing Cardiac Surgery

AUTHORS: Argalious, Maged Y. MD, MSc, MBA, MEd, FASE, FASA et al Anesthesia & Analgesia: March 2019 BACKGROUND: Data on testosterone replacement therapy and cardiovascular outcomes are conflicting, with the Food and Drug Administration requiring prescription testosterone preparations to indicate a possible increased cardiovascular risk. Whether patients on testosterone replacement therapy undergoing cardiac surgery have an increased […]

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Uncategorized Published - 24 July, 2019    By - Dr Clemens
Validation of a Second-Generation Near-Infrared Spectroscopy Monitor in Children With Congenital Heart Disease

AUTHORS: Nasr, Viviane G. MD et al Anesthesia & Analgesia: April 2019 – Volume 128 – Issue 4 – p 661-668 BACKGROUND: Cerebral oximetry using near-infrared spectroscopy is a noninvasive optical technology to detect cerebral hypoxia-ischemia and develop interventions to prevent and ameliorate hypoxic brain injury. Cerebral oximeters are calibrated and validated by comparison of the […]

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Uncategorized Published - 23 July, 2019    By - Dr Clemens
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes

AUTHORS: Shomorony, Andre BS et al Anesthesia & Analgesia: March 2019 BACKGROUND: Capsaicin, the active component of chili peppers, can produce sensory-selective peripheral nerve blockade. Coadministration of capsaicin and tetrodotoxin, a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks. However, capsaicin can be neurotoxic, and tetrodotoxin can cause systemic toxicity. […]

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Uncategorized Published - 23 July, 2019    By - Dr Clemens
Comparison of Programmed Intermittent Epidural Boluses With Continuous Epidural Infusion for the Maintenance of Labor Analgesia

AUTHORS: Ojo, Oluremi A. BS et al Anesthesia & Analgesia: March 2019 BACKGROUND: Programmed intermittent epidural boluses may improve the spread of local anesthetics compared to continuous epidural infusion, improving labor analgesia and obstetric outcomes. However, there are limited data from studies using commercially available pumps capable of coadministering programmed intermittent epidural boluses or continuous epidural infusion […]

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Uncategorized Published - 23 July, 2019    By - Dr Clemens
A Preoperative Cognitive Screening Test Predicts Increased Length of Stay in a Frail Population

AUTHORS: O’Reilly-Shah, Vikas N. MD, PhD et al Anesthesia & Analgesia: March 2019 BACKGROUND: Frailty is associated with adverse perioperative outcomes including major morbidity, mortality, and increased length of stay. We sought to elucidate the role that a preoperatively assessed Mini-Cog can play in assessing the risk of adverse perioperative outcomes in a population at high […]

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