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Uncategorized Published - 12 November, 2025    By - Dr Clemens
General anesthesia and systemic hyperosmolality modulate lumbar intrathecal drug distribution in female rats

Authors: Persson, Niklas Daniel Åke et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005794 This preclinical imaging study investigated how anesthesia type and systemic hyperosmolality affect the central nervous system (CNS) distribution of intrathecally administered drugs. The researchers examined the pharmacokinetics of a high–molecular weight spinal tracer (technetium-99m–labeled human serum albumin nanocolloid, 66.5 kDa) in female […]

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Uncategorized Published - 12 November, 2025    By - Dr Clemens
Cannabis Extract Relieves Chronic Low Back Pain: Phase 3 Study

Edited by Melissa Warburg Medscape A recent phase 3 study of more than 800 adults, published in Nature, revealed encouraging results for a cannabis extract in treating chronic low back pain, offering new hope for patients seeking nonopioid relief. VER-01, a full-spectrum Cannabis sativa extract, provided sustained pain reduction while also improving sleep quality and physical function, and without requiring […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
Neonatal outcomes with regional versus general anesthesia for cesarean delivery

Authors: Langer, Sarah et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005785 This meta-analysis of randomized controlled trials compared neonatal outcomes following cesarean delivery performed under regional anesthesia (spinal, epidural, or combined spinal-epidural) versus general anesthesia. Although regional techniques are widely preferred for maternal safety and recovery, their comparative effect on neonatal well-being has remained uncertain. […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
Mode of Anesthesia for Patients with Placenta Accreta Spectrum undergoing Cesarean Hysterectomy

Authors: Padilla, Andrew et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005788 This multicenter retrospective cohort study examined anesthetic practices for cesarean hysterectomy in patients with placenta accreta spectrum (PAS) using data from the Multicenter Perioperative Outcomes Group (MPOG) database. Placenta accreta, increta, and percreta represent progressively invasive forms of abnormal placentation associated with massive hemorrhage […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery

Authors: Wilson, Jenna et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005649 This prospective randomized controlled trial evaluated whether intraoperative ketamine reduces acute postsurgical pain in women undergoing breast cancer surgery, while also examining whether baseline temporal summation of pain (a measure of central sensitization) influences ketamine’s efficacy. A total of 225 patients were randomized to […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty

Authors: Zhu, Youzhuang et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005800 This randomized controlled trial evaluated whether S-ketamine can reduce postoperative delirium (POD) in elderly patients undergoing total hip or knee arthroplasty under neuraxial anesthesia. The study enrolled 372 patients between November 2023 and October 2024 at a high-volume arthroplasty center with standardized perioperative care […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC)

Authors: Shen, Fangming et al. Anesthesiology 2025 Oct 14 | DOI: 10.1097/ALN.0000000000005707 This multicenter randomized clinical trial (the AmPRAEC study) evaluated how different anesthesia-maintenance strategies affect postoperative respiratory adverse events (PRAEs) in children undergoing adenotonsillectomy. The investigators enrolled 760 children aged 0–12 years at 12 hospitals in China and randomly allocated them to one of […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
BEST Independent CRNA Opportunity – Savannah, TN

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]

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Uncategorized Published - 10 November, 2025    By - Dr Clemens
Cognitive Decline and Dementia in Chronic Widespread Pain

Authors: Jiang, Xue et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005731 This large longitudinal cohort study investigated whether chronic widespread pain (CWP) contributes to cognitive decline and dementia, as well as potential underlying mechanisms involving brain structure and systemic inflammation. Using data from nearly 190,000 UK Biobank participants followed over 13 years, researchers examined self-reported […]

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Uncategorized Published - 10 November, 2025    By - Dr Clemens
Modulation of the Renin–Angiotensin System in Critically Ill Patients

Authors: Calabrese, Alberto et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005633 This comprehensive narrative review examines the expanding role of renin–angiotensin system (RAS) modulation in critical care, focusing on both classical and alternative pathways. The authors explore how the dual RAS axes—one promoting vasoconstriction and inflammation, the other vasodilation and tissue protection—may be therapeutically targeted […]

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