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NEJM Journal Watch By Kelly Young Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Physical distancing of at least 1 meter (3.3 feet) is associated with lower risk for spread of coronaviruses, according to a meta-analysis in the Lancet. Researchers examined 44 studies on the effects of nonpharmaceutical interventions on the risk for transmitting […]
Read MoreAUTHORS: Alfahel, Waseem MD et al Anesthesia & Analgesia: April 2020 BACKGROUND: The use of a shoulder roll to view the glottic opening during direct laryngoscopy in infants has been recommended but is not evidence based. METHODS: Twenty infants with normal airways, <6 months of age undergoing elective surgery under general anesthesia were randomized to […]
Read MoreAUTHORS: Franz, Amber M. MD, MEng et al Anesthesia & Analgesia: April 2020 BACKGROUND: Opioids have been a central component of routine adult and pediatric anesthesia for decades. However, the long-term effects of perioperative opioids are concerning. Recent studies show a 4.8%–6.5% incidence of persistent opioid use after surgery in older children and adults. This […]
Read MoreAuthor: Mary Dale Peterson A guest column by the American Society of Anesthesiologists, exclusive to KevinMD.com. It is the ultimate irony that health care professionals on the front lines of the COVID-19 pandemic are among the highest risk, not only for exposure to the deadly virus, but economically. Whether they are inundated with COVID-19 patients […]
Read Moreapsf The unanticipated increased use of propofol as a sedative for ventilated patients has strained the nation’s propofol supply for intensive care units. As a result, the FDA has issued an Emergency Use Authorization (EUA) for emergency use of the Fresenius Kabi Propoven 2% Emulsion to maintain sedation via continuous infusion in patients 16 years and older who require […]
Read MoreAUTHORS: Mascha, Edward J. PhD et al Anesthesia & Analgesia: April 2020 Purpose: Healthcare worker (HCW) safety is of pivotal importance during a pandemic such as Coronavirus Disease 2019 (COVID-19), and employee health and well-being ensures functionality of healthcare institutions. This is particularly true for an intensive care unit (ICU) where highly specialized staff cannot be readily […]
Read MoreNEJM Journal Watch By Kelly Young Edited by Jaye Elizabeth Hefner, MD Preliminary results regarding the use of remdesivir against novel coronavirus disease (COVID-19) have been updated and published in the New England Journal of Medicine. (An earlier accounting, which we also reported here, led to the drug’s emergency approval by the FDA.) Over 1000 hospitalized patients […]
Read MoreAUTHORS: Zhang, Pengcheng MD et al Anesthesia & Analgesia: April 2020 – Volume 130 – Issue 4 – p 879-889 BACKGROUND: Whether intraoperative positive end-expiratory pressure (PEEP) can reduce the risk of postoperative pulmonary complications remains controversial. We performed a systematic review of currently available literature to investigate whether intraoperative PEEP decreases pulmonary complications in […]
Read MoreAUTHORS: Eley, Victoria A. PhD et al Anesthesia & Analgesia: April 2020 BACKGROUND: Obesity is a risk factor for surgical site infection after cesarean delivery. There is inadequate pharmacokinetic data available regarding prophylactic cefazolin dosing in obese pregnant women. We aimed to describe the plasma and interstitial fluid (ISF) pharmacokinetics of cefazolin in obese women […]
Read MoreAUTHORS: Burbridge, Mark A. MD Anesthesia & Analgesia: March 2020 BACKGROUND: Sugammadex is a modified cyclodextrin that is being increasingly used in anesthetic practice worldwide for the reversal of the aminosteroid neuromuscular blockers rocuronium and vecuronium. Its safety profile, however, is incompletely understood. One such aspect is the incidence of anaphylactic reactions that occur after […]
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