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Uncategorized Published - 29 January, 2021    By - Dr Clemens
Intermediate-dose anticoagulation, aspirin tied to lower incidence of in-hospital death among inpatients with COVID-19

DG Alerts Intermediate-dose anticoagulation and aspirin were each associated with a lower cumulative incidence of in-hospital death among hospitalised patients with coronavirus disease 2019 (COVID-19), according to a study published in the American Journal of Hematology. “High VTE (venous thromboembolism) rates have been reported in critically ill patients with COVID-19 despite the use of prophylactic anticoagulation,” […]

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Uncategorized Published - 28 January, 2021    By - Dr Clemens
Patient and Procedural Determinants of Postoperative Pain Trajectories

Authors: Terrie Vasilopoulos, Ph.D. et al  Anesthesiology January 2021. Background The primary goal of this study was to evaluate patterns in acute postoperative pain in a mixed surgical patient cohort with the hypothesis that there would be heterogeneity in these patterns. Methods This study included 360 patients from a mixed surgical cohort whose pain was […]

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Uncategorized Published - 28 January, 2021    By - Dr Clemens
Fast-spiking Interneurons Contribute to Propofol-induced Facilitation of Firing Synchrony in Pyramidal Neurons of the Rat Insular Cortex

Authors: Yuko Koyanagi, D.D.S., Ph.D. et al  Anesthesiology February 2021, Vol. 134, 219–233. Background The general anesthetic propofol induces frontal alpha rhythm in the cerebral cortex at a dose sufficient to induce loss of consciousness. The authors hypothesized that propofol-induced facilitation of unitary inhibitory postsynaptic currents would result in firing synchrony among postsynaptic pyramidal neurons that […]

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Uncategorized Published - 28 January, 2021    By - Dr Clemens
The Prevalence of Back and Leg Pain and the Cross-sectional Association With Adverse Health Outcomes in Community Dwelling Older Adults in England

DG Journal Club AUTHORS: Esther Williamson, Maria T Sanchez Santos et al. Spine (Phila Pa 1976). 2021 Jan 1; 46(1): 54-61 STUDY DESIGN Cross-sectional analysis of the Oxford Pain, Activity and Lifestyle (OPAL) Cohort Study. OBJECTIVE The aim of this study was to assess the prevalence of back pain (BP) and leg pain and determine […]

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Uncategorized Published - 28 January, 2021    By - Dr Clemens
Pregnant women unlikely to pass SARS-CoV-2 infection to newborns

DG Alerts A study published in JAMA Network Open shows that there was no maternal viremia, placental infection, or vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a cohort of pregnant women with coronavirus disease 2019 (COVID-19). In addition, compromised transplacental transfer of anti–SARS-CoV-2 antibodies with robust transfer of influenza-specific immunity and nonoverlapping placental […]

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Uncategorized Published - 28 January, 2021    By - Dr Clemens
Current, former smokers with COVID-19 twice as likely to need hospital care

Autor: Brian P. Dunleavy UPI Smokers are at higher risk for hospitalization and death than non-smokers who contract COVID-19, a new study has found. Current and former long-time smokers are more than twice as likely to require hospital care after being infected with COVID-19 and nearly twice as likely to die from the virus compared to those […]

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Uncategorized Published - 27 January, 2021    By - Dr Clemens
Neuromuscular Blockade Monitoring in Acute Respiratory Distress Syndrome

AUTHORS: Rezaiguia-Delclaux, Saïda MD et al Anesthesia & Analgesia: September 2020 BACKGROUND: Whether train-of-four (TOF) monitoring is more effective than clinical monitoring to guide neuromuscular blockade (NMB) in patients with acute respiratory distress syndrome (ARDS) is unclear. We compared clinical monitoring alone or with TOF monitoring to guide atracurium dosage adjustment with respect to drug […]

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Uncategorized Published - 27 January, 2021    By - Dr Clemens
An assessment of perioperative respiratory adverse events and difficult intubation in pediatric patients with trisomy 21

DG Journal Club AUTHORS: Taylor Graber, Paola Baskin et al. Paediatr Anaesth. 2021 Jan INTRODUCTION Several prior studies have demonstrated an association between trisomy 21 and airway-related anesthetic complications. However, there is a paucity of large clinical studies characterizing the airway challenges associated with trisomy 21. In this analysis we examine anesthetic related airway complications […]

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Uncategorized Published - 27 January, 2021    By - Dr Clemens
High-frequency spinal cord stimulation in failed back surgery syndrome patients with predominant low back pain-single-center experience

DG Journal Club Authors: Stefan Motov, Kaywan Aftahy et al. Neurosurg Rev. 2021 Jan Treatment of patients with failed back surgery syndrome (FBSS) with predominant low back pain (LBP) remains challenging. High-frequency spinal cord stimulation (HF10 SCS) is believed to achieve significant pain reduction. We aimed to evaluate the real-life efficacy of HF-10 SCS in […]

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Uncategorized Published - 27 January, 2021    By - Dr Clemens
An Electroencephalogram Metric of Temporal Complexity Tracks Psychometric Impairment Caused by Low-dose Nitrous Oxide

Authors: Xavier C. E. Vrijdag, M.Sc. et al  Anesthesiology February 2021, Vol. 134, 202–218. Background Nitrous oxide produces non–γ-aminobutyric acid sedation and psychometric impairment and can be used as scientific model for understanding mechanisms of progressive cognitive disturbances. Temporal complexity of the electroencephalogram may be a sensitive indicator of these effects. This study measured psychometric performance […]

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