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Uncategorized Published - 9 February, 2021    By - Dr Clemens
Real-Time Intraoperative Determination and Reporting of Cerebral Autoregulation State Using Near-Infrared Spectroscopy

AUTHORS: Montgomery, Dean PhD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1520-1528 BACKGROUND:  Cerebral blood flow (CBF) is maintained over a range of blood pressures through cerebral autoregulation (CA). Blood pressure outside the range of CA, or impaired autoregulation, is associated with adverse patient outcomes. Regional oxygen […]

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Uncategorized Published - 9 February, 2021    By - Dr Clemens
Utilization Patterns of Perioperative Neuromuscular Blockade Reversal in the United States

AUTHORS: Dubovoy, Timur Z. MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1510-1519 BACKGROUND:  Following the introduction of sugammadex to the US clinical practice, scarce data are available to understand its utilization patterns. This study aimed to characterize patient, procedure, and provider factors associated with sugammadex administration […]

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Uncategorized Published - 9 February, 2021    By - Dr Clemens
Subset of COVID-19 patients have increased bleeding risk

DG Alerts Patients with coronavirus disease 19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions; however, in a subset of patients, there is also a risk of bleeding complications, according to a study published in Scientific Reports. “While the prothrombotic risk associated with COVID-19 is well recognised, the risk of bleeding should not […]

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Uncategorized Published - 8 February, 2021    By - Dr Clemens
Exposure to General Anesthesia for Cesarean Delivery and Odds of Severe Postpartum Depression Requiring Hospitalization

AUTHORS: Guglielminotti, Jean MD, PhD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1421-1429 BACKGROUND:  Previous research suggests that, compared with regional anesthesia, general anesthesia is associated with increased odds of postoperative depressive disorders. No study has specifically evaluated the possible protective effect of neuraxial anesthesia for cesarean […]

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Uncategorized Published - 8 February, 2021    By - Dr Clemens
The Perioperative Implementation of a Hypertension Protocol by Anesthesiologists

AUTHORS: Pfister, Claire-Louise MBChB, BSc, DA, DCH et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1401-1408 BACKGROUND:  Hypertension is a common risk factor for cardiovascular morbidity and mortality, with a high prevalence in patients presenting for elective surgery. In limited resource environments, patients have poor access to primary […]

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Uncategorized Published - 8 February, 2021    By - Dr Clemens
Study suggests microthrombi is a major cause of cardiac injury in COVID-19

DG Alerts An autopsy study published in Circulation finds that 35% of patients dying with coronavirus disease 2019 (COVID-19) had evidence of cardiac injury identified by the presence of myocyte necrosis, while the most common pathologic cause of myocyte necrosis was microthrombi. “Cardiac injury is common in hospitalised patients with COVID-19 and portends poorer prognosis. However, the […]

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Uncategorized Published - 8 February, 2021    By - Dr Clemens
Neither Preoperative Pulse Pressure nor Systolic Blood Pressure Is Associated With Cardiac Complications After Coronary Artery Bypass Grafting

AUTHORS: Zhang, Kan MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1491-1499 BACKGROUND:  Increased pulse pressure has been associated with adverse cardiovascular events, cardiac and all-cause mortality in surgical and nonsurgical patients. Whether increased pulse pressure worsens myocardial injury and dysfunction after cardiac surgery, however, has not […]

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Uncategorized Published - 8 February, 2021    By - Dr Clemens
Effect of Perioperative Active Body Surface Warming Systems on Analgesic and Clinical Outcomes

AUTHORS: Balki, Indranil HBSc, MD Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1430-1443 BACKGROUND:  Inadvertent perioperative hypothermia is a common complication of surgery, and active body surface warming (ABSW) systems are used to prevent adverse clinical outcomes. Prior data on certain outcomes are equivocal (ie, blood loss) or limited (ie, […]

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Uncategorized Published - 8 February, 2021    By - Dr Clemens
The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects

AUTHORS: Ingrande, Jerry MD, MS et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1500-1509 BACKGROUND:  Induction of anesthesia is a phase characterized by rapid changes in both drug concentration and drug effect. Conventional mammillary compartmental models are limited in their ability to accurately describe the early drug distribution […]

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Uncategorized Published - 5 February, 2021    By - Dr Clemens
Thromboelastographic Assessment of Fibrinolytic Activity in Postpartum Hemorrhage

AUTHORS: Arnolds, David E. MD, PhD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1373-1379 BACKGROUND:  Postpartum hemorrhage is a leading cause of maternal mortality. Antifibrinolytic therapy has the potential to influence outcomes in postpartum hemorrhage, but the incidence of elevated fibrinolytic activity in postpartum hemorrhage is unknown. […]

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