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Uncategorized Published - 11 February, 2021    By - Dr Clemens
New Nonopioid for Post-Surgical Pain Reduction Granted FDA Approval

Pharmacy Times Officials with the FDA have approved bupivacaine solution (Posimir; DURECT Corporation) for infiltration use in adults. The drug is a novel, nonopioid, sustained-release local analgesic indicated for use as postsurgical analgesia for up to 72 hours following arthroscopic subacromial decompression. It is administered into the subacromial space under direct arthroscopic visualization. “The first 72 […]

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Uncategorized Published - 11 February, 2021    By - Dr Clemens
Comprehensive Risk Assessment of Morbidity in Pediatric Patients Undergoing Noncardiac Surgery

AUTHORS: Nasr, Viviane G. MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1607-1615 BACKGROUND:  Utilizing the intrinsic surgical risk (ISR) and the patient’s chronic and acute conditions, this study aims to develop and validate a comprehensive predictive model of perioperative morbidity in children undergoing noncardiac surgery. METHODS: […]

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Uncategorized Published - 11 February, 2021    By - Dr Clemens
Perioperative Allogeneic Red Blood Cell Transfusion and Wound Infections

AUTHORS: Yuan, Yuchen MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1573-1581 BACKGROUND:  It remains unclear whether the benefits of performing perioperative allogeneic red blood cell (RBC) transfusion outweigh the risks of postoperative wound infection. The aim of this study was to assess the impact of perioperative RBC […]

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Uncategorized Published - 10 February, 2021    By - Dr Clemens
The Median Effective Dose of One Intravenous Bolus of Oxycodone for Postoperative Analgesia After Myomectomy and Hysterectomy With Local Ropivacaine Wound Infiltration: An Up–Down Dose-Finding Study

AUTHORS: Yu, Wantong MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1599-1606 BACKGROUND:  Oxycodone has been shown to be an effective analgesic for early postoperative analgesia, especially for abdominal operations associated with severe visceral pain. However, the dose needed varies depending on the operation and application of […]

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Uncategorized Published - 10 February, 2021    By - Dr Clemens
Comparison of Pupillometry With Surgical Pleth Index Monitoring on Perioperative Opioid Consumption and Nociception During Propofol–Remifentanil Anesthesia

AUTHORS: Kim, Jong Hae MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1589-1598 BACKGROUND:  Intraoperative monitoring with pupillometry has shown promising results for nociception/antinociception balance monitoring. However, its benefits in clinical practice remain unproven. The aim of this study was to evaluate the efficacy of intraoperative pupillometry […]

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Uncategorized Published - 10 February, 2021    By - Dr Clemens
Safety of the LMA®Gastro™ for Endoscopic Retrograde Cholangiopancreatography

AUTHORS: Hagan, Katherine B. MD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1566-1572 BACKGROUND:  Endoscopic retrograde cholangiopancreatography (ERCP) patients typically receive either tubeless anesthesia or general endotracheal anesthesia (GETA). Patients receiving propofol-based total intravenous anesthesia (TIVA) are at higher risk of sedation-related adverse events (SRAEs) than patients […]

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Uncategorized Published - 10 February, 2021    By - Dr Clemens
Analysis of 1478 Cases of Hypospadias Repair: The Incidence of Requiring Repeated Anesthetic Exposure as Well as Exploration of the Involvement of Trainees on Case Duration

AUTHORS: Adler, Adam C. MS, MD, FAAP, FASE et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1551-1556 BACKGROUND:  Recently, there has been significant focus on the effects of anesthesia on the developing brain. Concern is heightened in children <3 years of age requiring lengthy and/or multiple anesthetics. Hypospadias […]

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Uncategorized Published - 10 February, 2021    By - Dr Clemens
Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a “Vulnerable Brain”

AUTHORS: Shao, Yu Raymond MD, PhD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1529-1539 BACKGROUND:  A number of recent studies have reported an association between intraoperative burst suppression and postoperative delirium. These studies suggest that anesthesia-induced burst suppression may be an indicator of underlying brain vulnerability. A prominent […]

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Uncategorized Published - 9 February, 2021    By - Dr Clemens
Preoperative Frailty Predicts Postoperative Neurocognitive Disorders After Total Hip Joint Replacement Surgery

AUTHORS: Evered, Lis A. PhD et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1582-1588 BACKGROUND:  Frailty is a reduced capacity to recover from a physiologically stressful event. It is well established that preoperative frailty is associated with poor postoperative outcomes, but it is unclear if this includes cognitive […]

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Uncategorized Published - 9 February, 2021    By - Dr Clemens
Arterial Catheters for Early Detection and Treatment of Hypotension During Major Noncardiac Surgery

AUTHORS: Naylor, Amanda J. MA et al Anesthesia & Analgesia: November 2020 – Volume 131 – Issue 5 – p 1540-1550 BACKGROUND:  Continuous blood pressure monitoring may facilitate early detection and prompt treatment of hypotension. We tested the hypothesis that area under the curve (AUC) mean arterial pressure (MAP) <65 mm Hg is reduced by continuous […]

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