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Uncategorized Published - 9 August, 2021    By - Dr Clemens
A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects

AUTHORS: Sadhasivam, Senthilkumar MD, MPH, MBA, FASA et al Anesthesia & Analgesia: August 2021 – Volume 133 – Issue 2 – p 327-337 BACKGROUND:  Intraoperative methadone, a long-acting opioid, is increasingly used for postoperative analgesia, although the optimal methadone dosing strategy in children is still unknown. The use of a single large dose of intraoperative methadone […]

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Uncategorized Published - 9 August, 2021    By - Dr Clemens
Psychological factors associated with headache frequency, intensity, and headache-related disability in migraine patients

DG Journal Club AUTHORS: Theresa Klonowski, Peter Kropp et al. Neurol Sci. 2021 Jul 25 BACKGROUND Several psychological cofactors of migraine have been identified, but relationships to different headache parameters (e.g., headache frequency vs. headache-related disability) are only incompletely understood. METHODS We cross-sectionally assessed 279 migraine patients at their first presentation at our tertiary headache […]

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Uncategorized Published - 9 August, 2021    By - Dr Clemens
GABAergic Neurons in the Dorsal–Intermediate Lateral Septum Regulate Sleep–Wakefulness and Anesthesia in Mice

Authors: Di Wang, M.D. et al  Anesthesiology July 2021. Background The γ-aminobutyric acid–mediated (GABAergic) inhibitory system in the brain is critical for regulation of sleep–wake and general anesthesia. The lateral septum contains mainly GABAergic neurons, being cytoarchitectonically divided into the dorsal, intermediate, and ventral parts. This study hypothesized that GABAergic neurons of the lateral septum […]

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Uncategorized Published - 6 August, 2021    By - Dr Clemens
Prevention of Cardiac Surgery–Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers

AUTHORS: Zarbock, Alexander MD et al Anesthesia & Analgesia: August 2021 – Volume 133 – Issue 2 – p 292-302 BACKGROUND:  Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced the development of acute kidney injury (AKI) after surgery. We sought to evaluate […]

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Uncategorized Published - 6 August, 2021    By - Dr Clemens
Relationship Between Intraoperative and Preoperative Ambulatory Nighttime Heart Rates

AUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: August 2021 – Volume 133 – Issue 2 – p 406-412 BACKGROUND:  It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory […]

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Uncategorized Published - 6 August, 2021    By - Dr Clemens
Prediction of Prolonged Opioid Use After Surgery in Adolescents: Insights From Machine Learning

AUTHORS: Ward, Andrew PhD et al Anesthesia & Analgesia: August 2021 – Volume 133 – Issue 2 – p 304-313 BACKGROUND:  Long-term opioid use has negative health care consequences. Patients who undergo surgery are at risk for prolonged opioid use after surgery (POUS). While risk factors have been previously identified, no methods currently exist to determine […]

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Uncategorized Published - 6 August, 2021    By - Dr Clemens
Effects of the ABCB1 c.3435C>T (rs1045642) Polymorphism on Heat Pain Perception in Opioid-Free Adults With Chronic Pain

AUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain (HP) […]

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Uncategorized Published - 6 August, 2021    By - Dr Clemens
Corticosteroid injections in the temporomandibular joint temporarily alleviate pain and improve function in rheumatoid arthritis

DG Journal Club AUTHORS: Johanna Margaretha Kroese, Sigvard Kopp et al. Clin Rheumatol. 2021 Jul 21 OBJECTIVES To evaluate the effect of corticosteroid injections in the painful temporomandibular joint (TMJ) of patients with rheumatoid arthritis (RA) in relation to systemic inflammatory activity. METHOD Examination of 35 patients (median age 54 years; 89% female) included maximum mouth […]

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Uncategorized Published - 5 August, 2021    By - Dr Clemens
Effects of Local Anesthetic Volume (Standard Versus Low) on Incidence of Hemidiaphragmatic Paralysis and Analgesic Quality for Ultrasound-Guided Superior Trunk Block After Arthroscopic Shoulder Surgery

AUTHORS: Kim, Hyunzu MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Relative to interscalene block, superior trunk block (STB) provides comparable analgesia and a reduced risk of hemidiaphragmatic paralysis. However, the incidence of hemidiaphragmatic paralysis remains high when a standard volume (15 mL) of local anesthetic is used. This study aimed to evaluate the […]

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Uncategorized Published - 5 August, 2021    By - Dr Clemens
The Facilitatory Effects of Adjuvant Pharmaceutics to Prolong the Duration of Local Anesthetic for Peripheral Nerve Block

AUTHORS: Xuan, Chengluan MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: Peripheral nerve block (PNB) with perineural local anesthetic is used for anesthesia or analgesia with many benefits. To extend these benefits, various adjuvant drugs have been used to prolong the duration of analgesia. We aimed to evaluate the effectiveness of various adjuvants at […]

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