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DG Alerts Normalisation of central nervous system (CNS) injury biomarkers in all individuals, regardless of previous disease severity or persisting neurological symptoms, indicates that post coronavirus disease 2019 (COVID-19) neurological sequelae are not accompanied by ongoing CNS injury, according to a study published in EBioMedicine. “To the best of our knowledge, this is the first study […]
Read MoreDG Journal Club AUTHORS Ed Carlos Rey Moura, Andrey Salgado Moraes Filho et al. Obes Surg. 2021 Jul 5 INTRODUCTION Patients with obesity have anatomical changes due to increased adipose tissue that negatively affect airway accessibility, making it difficult to establish an advanced airway through orotracheal intubation. This article aims to evaluate the correlation of […]
Read MoreDG Alerts Studies published in The New England Journal of Medicine showed that treating moderately ill hospitalised coronavirus disease 2019 (COVID-19) patients with therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. However, the use of this treatment strategy for […]
Read MoreAuthors: Mahmoud Hasan, Ph.D. et al Anesthesiology August 2021, Vol. 135, 326–339. Background The anesthetic ketamine after intravenous dosing is nearly completely metabolized to R- and S-stereoisomers of the active norketamine (analgesic, psychoactive) and 2,6-hydroxynorketamine (potential analgesic, antidepressant) as well as the inactive dehydronorketamine. Oral administration favors the formation of 2,6-hydroxynorketamines via extensive presystemic metabolism. The authors […]
Read MoreAuthor: Richard Novak, MD The Anesthesia Consultant What can we expect in the next 10 years of anesthesiology? What will be the trends for the future of anesthesiology? I’m writing this from the perspective of a busy clinician who has worked as an anesthesiologist in California in both private practice and at a major university […]
Read MoreDG Journal Club AUTHORS: Shaalini Ramanadhan, Elisabeth Woodhams et al. Contraception. 2021 Jul 5 OBJECTIVE To assess sedation medication dosage differences between patients with and without opioid use disorder at the time of surgical abortion. STUDY DESIGN We performed a retrospective cohort study, identifying patients obtaining a surgical abortion in our ambulatory procedure unit between […]
Read MoreAuthor: Cardiac Anesthesiologist Anesthesia providers should be familiar with the pharmacologic alterations of anesthetics in obese individuals. In general, manufacturer dosing recommendations are scaled to kilograms of actual total body weight (TBW). However, anesthesia providers rarely use mg/kg dosing in obese patients for fear of administering an excessive dose (e.g., a 136-kg patient does not […]
Read MoreAuthors: Eric D. Melonakos, Ph.D. et al Anesthesiology July 2021. Background Parabrachial nucleus excitation reduces cortical delta oscillation (0.5 to 4 Hz) power and recovery time associated with anesthetics that enhance γ-aminobutyric acid type A receptor action. The effects of parabrachial nucleus excitation on anesthetics with other molecular targets, such as dexmedetomidine and ketamine, remain […]
Read MoreAuthors: Meg E. Carley, B.Sc. et al Anesthesiology August 2021, Vol. 135, 304–325. Background Chronic postsurgical pain can severely impair patient health and quality of life. This systematic review update evaluated the effectiveness of systemic drugs to prevent chronic postsurgical pain. Methods The authors included double-blind, placebo-controlled, randomized controlled trials including adults that evaluated perioperative […]
Read MoreAuthors: Kerstin Kolodzie, M.D., Ph.D., M.A.S. et al Anesthesiology July 2021. Background Perioperative normal saline administration remains common practice during kidney transplantation. The authors hypothesized that the proportion of balanced crystalloids versus normal saline administered during the perioperative period would be associated with the likelihood of delayed graft function. Methods The authors linked outcome data from a […]
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