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Uncategorized Published - 23 August, 2021    By - Dr Clemens
Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates

Authors: Huiping Ding, Ph.D. et al  Anesthesiology September 2021, Vol. 135, 482–493. Background Cebranopadol, a mixed nociceptin/opioid receptor full agonist, can effectively relieve pain in rodents and humans. However, it is unclear to what degree different opioid receptor subtypes contribute to its antinociception and whether cebranopadol lacks acute opioid-associated side effects in primates. The authors […]

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Uncategorized Published - 20 August, 2021    By - Dr Clemens
Lidocaine infusions and reduced opioid consumption-Retrospective experience in pediatric hematology and oncology patients with refractory pain

DG Journal Club AUTHORS Doralina L Anghelescu, Kyle J Morgan et al. Pediatr Blood Cancer. 2021 Jul 15 BACKGROUND Despite a more robust experience with lidocaine infusions for pain management in adults and general pediatric population, there is limited evidence of efficacy of lidocaine infusions for pain management in patients with pediatric hematology and oncology […]

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Uncategorized Published - 20 August, 2021    By - Dr Clemens
Ibuprofen and COVID-19: Is it safe?

Author: Aaron Kadola Medical News Today Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It can reduce inflammation and ease several symptoms, including pain and fever. It is safe for people with COVID-19 to take — there is no evidence that ibuprofen increases the risk of harm from COVID-19 or the vaccines that protect against this […]

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Uncategorized Published - 20 August, 2021    By - Dr Clemens
How Pregabalin (LYRICA) Works?

Author: Cardiac Anesthesiologist Mechanism of action: Mechanism of action of pregabalin has not been exactly explained. It binds with high affinity to the alpha2-delta site – subunit of voltage-dependent calcium channels in central nervous system.Thus, calcium currents decrease, which may be associated with the antinociceptive and antiseizure effects of pregabalin. Nociception is the recognizing of painful stimuli.   What pregabalin is indicated for? Pregabalin […]

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Uncategorized Published - 19 August, 2021    By - Dr Clemens
Infection Control during Anaesthetic Procedures

Author: Cardiac Anesthesiologist The risk of infection is dependent on the procedure and the level of barrier protection. Guidelines for monitoring have been published by the Association of Anaesthetists and should be followed at all times. Infection control while using ultrasound. Ultrasound is used for many anaesthetic procedures. The probe should have a sterile protective cover for each […]

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Uncategorized Published - 19 August, 2021    By - Dr Clemens
Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain

DG Journal Club AUTHORS Ellyn K Dunbar, Phil J Greer et al. Am J Gastroenterol. 2021 Jul 8 INTRODUCTION Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are progressive inflammatory syndromes with variable features. Pain is the primary feature that contributes to low physical and mental quality of life with a third of patients reporting […]

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Uncategorized Published - 19 August, 2021    By - Dr Clemens
Can COVID-19 cause headaches?

Author: Aaron Kadola Medical News Today COVID-19 causes a range of symptoms, including headaches that can vary from person to person. These headaches may feel like a pulsating or stabbing sensation in the head. They may last a few days and go away on their own or require treatment. Headaches are a common health complaint. […]

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Uncategorized Published - 18 August, 2021    By - Dr Clemens
Individualized positive end-expiratory pressure (PEEP) during one-lung ventilation for prevention of postoperative pulmonary complications in patients undergoing thoracic surgery

DG Journal Club AUTHORS Pule Li, Xia Kang et al. Medicine (Baltimore). 2021 Jul 16 BACKGROUND Positive end-expiratory pressure (PEEP) is an important part of the lung protection strategies for one-lung ventilation (OLV). However, a fixed PEEP value is not suitable for all patients. Our objective was to determine the prevention of individualized PEEP on […]

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Uncategorized Published - 18 August, 2021    By - Dr Clemens
FAILED INTUBATION

Author: George Kovacs Cardiac Anesthesiologist Continue BMV between attempts, call for help and remember each attempt mandates a different approach. 1. If SpO2 permits allow a maximum of 3 attempts. 2. For direct or Macintosh videolaryngoscopy optimize technique, ELM, head position and consider using adjuncts. 3. If there is hold up at the glottic inlet when using a bougie, rotate […]

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Uncategorized Published - 17 August, 2021    By - Dr Clemens
Postdischarge Nonsteroidal Anti-Inflammatory Drugs Are not Associated with Risk of Hematoma after Lumpectomy and Sentinel Lymph Node Biopsy with Multimodal Analgesia

DG Journal Club AUTHORS: Kate R Pawloski, Regina Matar et al. Ann Surg Oncol. 2021 Jul 10 BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are increasingly used in ambulatory breast surgery. The risk of hematoma associated with intraoperative ketorolac is low, but whether concomitant routine discharge with NSAIDs increases the risk of hematoma is unclear. METHODS We […]

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