Uncategorized Published - 4 October, 2021 By - Dr Clemens

Intrathecal Morphine for Analgesia in Minimally Invasive Cardiac Surgery

Authors: Richa Dhawan, M.D., M.P.H. et al Anesthesiology September 2021. Background Intrathecal morphine decreases postoperative pain in standard cardiac surgery. Its safety and effectiveness have not been adequately evaluated in minimally invasive cardiac surgery. The authors hypothesized that intrathecal morphine would decrease postoperative morphine consumption after minimally invasive cardiac surgery. Methods In this randomized, placebo-controlled, […]

Uncategorized Published - 4 October, 2021 By - Dr Clemens

Neurophysiologic Complexity in Children Increases with Developmental Age and Is Reduced by General Anesthesia

Authors: Michael P. Puglia, II, M.D., Ph.D. et al Anesthesiology September 2021. Background Neurophysiologic complexity in the cortex has been shown to reflect changes in the level of consciousness in adults but remains incompletely understood in the developing brain. This study aimed to address changes in cortical complexity related to age and anesthetic state transitions. […]

Uncategorized Published - 4 October, 2021 By - Dr Clemens

Smart Glasses for Radial Arterial Catheterization in Pediatric Patients

Authors: Young-Eun Jang, M.D. et al Anesthesiology October 2021, Vol. 135, 612–620. Background Hand–eye coordination and ergonomics are important for the success of delicate ultrasound-guided medical procedures. These can be improved using smart glasses (head-mounted display) by decreasing the head movement on the ultrasound screen. The hypothesis was that the smart glasses could improve the […]

Uncategorized Published - 4 October, 2021 By - Dr Clemens

Ipsilateral and Simultaneous Comparison of Responses from Acceleromyography- and Electromyography-based Neuromuscular Monitors

Authors: Réka Nemes, M.D. et al Anesthesiology October 2021, Vol. 135, 597–611. Background The paucity of easy-to-use, reliable objective neuromuscular monitors is an obstacle to universal adoption of routine neuromuscular monitoring. Electromyography (EMG) has been proposed as the optimal neuromuscular monitoring technology since it addresses several acceleromyography limitations. This clinical study compared simultaneous neuromuscular responses recorded […]

Uncategorized Published - 4 October, 2021 By - Dr Clemens

New Report: Costs of Caring for Sicker Patients to Drive Continued Hospital and Health System Losses Throughout 2021

American Hospital Association Hospitals are treating sicker patients, spending more for labor, supplies and equipment as people continue to put off care A new analysis prepared by Kaufman, Hall & Associates, LLC and released today by the American Hospital Association shows that higher expenses for labor, drugs and supplies as well as patients putting off care […]

Uncategorized Published - 1 October, 2021 By - Dr Clemens

Incidence, Mortality, and Characteristics of 18 Pediatric Perioperative Cardiac Arrests

AUTHORS: Jansen, Gerrit Dr med et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 747-754 BACKGROUND: Recently, a very low incidence of 3 per 10,000 and a mortality of 30% were reported for pediatric perioperative cardiac arrest (POCA). However, high-risk patients, namely children already anesthetized on the intensive care unit […]

Uncategorized Published - 1 October, 2021 By - Dr Clemens

REsidual Neuromuscular Block Prediction Score Versus Train-of-Four Ratio and Respiratory Outcomes

AUTHORS: Patrocínio, Maria D. MD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 610-619 BACKGROUND: Residual neuromuscular blockade is associated with an increased incidence of postoperative respiratory complications. The REsidual neuromuscular block Prediction Score (REPS) identifies patients at high risk for residual neuromuscular blockade after surgery. METHODS: A total […]

Uncategorized Published - 1 October, 2021 By - Dr Clemens

Pharmacologic Management of Intensive Care Unit Delirium

AUTHORS: Boncyk, Christina S. MD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 713-722 BACKGROUND: Pharmacologic agents are frequently utilized for management of intensive care unit (ICU) delirium, yet prescribing patterns and impact of medication choices on patient outcomes are poorly described. We sought to describe prescribing practices for […]

Uncategorized Published - 1 October, 2021 By - Dr Clemens

P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8–Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion

AUTHORS: Su, Lin MD, PhD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 794-810 BACKGROUND: Remifentanil can induce postinfusion cold hyperalgesia. N-methyl-d-aspartate receptor (NMDAR) activation and upregulation of transient receptor potential melastatin 8 (TRPM8) membrane trafficking in dorsal root ganglion (DRG) are critical to cold hyperalgesia derived from neuropathic pain, […]

Uncategorized Published - 1 October, 2021 By - Dr Clemens

Activation of Orexinergic Neurons Inhibits the Anesthetic Effect of Desflurane on Consciousness State via Paraventricular Thalamic Nucleus in Rats

AUTHORS: Zhao, Shiyi MD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 781-793 BACKGROUND: Orexin, a neuropeptide derived from the perifornical area of the hypothalamus (PeFLH), promotes the recovery of propofol, isoflurane, and sevoflurane anesthesias, without influencing the induction time. However, whether the orexinergic system also plays a similar […]