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Author: Katsuyuki Miyasaka, MD, PhD Anesthesia Patient Safety Foundation Vol 36 No 3 Oct 2021 Oximetry: Principle, but No Theory I am from a generation that experienced anesthesiology before the development of pulse oximeters. I was studying abroad in North America from 1973–1977, when Takuo Aoyagi, PhD, envisioned the principle of pulse oximetry. This was […]
Read MoreAuthor: Tony Mira F1rstNews We all know that anesthesia is an essential element in the running of an operating room. It is the anesthesia provider who makes it possible for the surgeon to successfully perform the procedure. Patients must remain motionless, be pain free and not have any unexpected reactions to the trauma of the […]
Read MoreAUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1028-1035 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the […]
Read MoreAUTHORS: Ye, Yingchao MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1048-1059 BACKGROUND: Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine. Bupivacaine can inhibit protein kinase B (AKT) phosphorylation and activated adenosine monophosphate–activated protein kinase alpha (AMPKα). It can decouple mitochondrial oxidative phosphorylation and […]
Read MoreAUTHORS: Ilfeld, Brian M. MD, MS et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1019-1027 BACKGROUND: We recently reported that a 6-day continuous peripheral nerve block reduced established postamputation phantom pain 3 weeks after treatment ended. However, the immediate effects of perineural infusion (secondary outcomes) have yet to be […]
Read MoreAUTHORS: Lo, Calvin MD, MSc et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 984-990 BACKGROUND: Adolescent idiopathic scoliosis (AIS) surgery is associated with significant postoperative pain. Remifentanil is a short-acting opioid that is often used as a component of total intravenous anesthesia. Remifentanil has been implicated in acute opioid […]
Read MoreAUTHORS: Packiasabapathy, Senthil MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 991-999 BACKGROUND: Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification […]
Read MoreAUTHORS: Schopfer, Leonore MMSc et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 976-983 BACKGROUND: Mechanical ventilation interferes with cerebral perfusion via changes in intrathoracic pressure and/or as a consequence of alterations in CO2. Cerebral vascular vasoreactivity is dependent on CO2, and hypocapnia can potentially lead to vasoconstriction and subsequent […]
Read MoreAUTHORS: Davies, Simon J. MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1060-1069 BACKGROUND: Intraoperative hypotension is a common event, and a recent study suggests that maintenance of blood pressure may reduce complications. The splanchnic circulation provides a reservoir of blood that can be mobilized during hemorrhage; hence, […]
Read MoreAUTHORS: Weiniger, Carolyn F. MB, ChB et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 967-975 BACKGROUND: Low-dose (≤8 mg) hyperbaric bupivacaine for spinal anesthesia during cesarean delivery results in reduced efficacy, yet as a secondary outcome was associated with reduced frequency of spinal-induced hypotension. Our primary aim was […]
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