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AUTHORS: Fassbender, Philipp MD et al Anesthesia & Analgesia: December 2021 – Volume BACKGROUND: The G-protein–coupled receptor kinase 5 (GRK5) is a mediator of cardiovascular homeostasis and participates in inflammation and cardiac fibrosis, both being involved in the development of diastolic dysfunction (DD). While mechanisms of transcriptional regulation of the GRK5 promoter are unclear, we tested […]
Read MoreAUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: December 2021 BACKGROUND: Cardiac output is an important hemodynamic variable and determines oxygen delivery. In contrast to blood pressure, cardiac output is rarely measured even in high-risk surgical patients, suggesting that clinicians consider blood pressure to be a reasonable indicator of systemic blood flow. However, the relationship […]
Read MoreAUTHORS: Pensier, Joris MD et al Anesthesia & Analgesia: November 2021 BACKGROUND: In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch (HES) solutions have been raised. However, HES solutions may yet have a role to play in major abdominal surgery. This meta-analysis and trial sequential analysis (TSA) […]
Read MoreAUTHORS: Aykanat, Verna M. FANZCA, MBBS, BMedSci (Hons) et al Anesthesia & Analgesia: December 2021 BACKGROUND: Prevention of hypotension during the intra- and postoperative period is an important goal. Peripheral administration of low-concentration norepinephrine may be a safe and effective strategy to reduce the risk of hypotension. METHODS: We conducted a 2-center, randomized pilot feasibility trial, […]
Read MoreAUTHORS: Murugesan, Saravanakumar PhD Anesthesia & Analgesia: December 2021 BACKGROUND: Preeclampsia (PE) manifesting as hypertension and organ injury is mediated by vascular dysfunction. In biological fluids, extracellular vesicles (EVs) containing microRNA (miRNA), protein, and other cargo released from the placenta may serve as carriers to propagate injury, altering the functional phenotype of endothelial cells. PE has […]
Read MoreAUTHORS: Pensier, Joris MD et al Anesthesia & Analgesia: November 2021 BACKGROUND: In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch (HES) solutions have been raised. However, HES solutions may yet have a role to play in major abdominal surgery. This meta-analysis and trial sequential analysis (TSA) […]
Read MoreAUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: December 2021 BACKGROUND: Cardiac output is an important hemodynamic variable and determines oxygen delivery. In contrast to blood pressure, cardiac output is rarely measured even in high-risk surgical patients, suggesting that clinicians consider blood pressure to be a reasonable indicator of systemic blood flow. However, the relationship […]
Read MoreCardiac Anesthesiologist Before the initiation of anesthetic care or airway management, assure that an airway risk assessment is performed by the person(s) responsible for airway management whenever feasible to identify patient, medical, surgical, environmental, and anesthetic factors (e.g., risk of aspiration) that may indicate the potential for a difficult airway. o When available in the patient’s […]
Read MoreDG News Author: Erika Powers A novel multimodal analgesia pathway was associated with decreased periprocedural opioid consumption for patients undergoing CT-guided percutaneous hepatic microwave ablation, according to a study presented at Anesthesiology 2021, the Annual Meeting of the American Society of Anesthesiologists (ASA). “There is a growing need to manage acute periprocedural pain for patients […]
Read MoreDG Journal Club AUTHORS: AndrC) Dos Santos Rocha, Walid Habre et al. Paediatr Anaesth. 2021 Nov 27 Extraordinary progress has been made during the past few decades in the development of anesthesia machines and ventilation techniques. With unprecedented precision and performance, modern machines for pediatric anesthesia can deliver appropriate mechanical ventilation for children and infants […]
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