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Uncategorized Published - 27 September, 2022    By - Dr Clemens
Remifentanil as a Soft Drug Prototype

Radius Anesthesia A “soft drug” is an active compound that can easily be transformed into an inactive metabolite in the body [1]. Anesthesiology requires careful consideration of three axes: safety, effectiveness, and efficiency [2]. In medical practice, the third axis (efficiency) is often less prioritized; however, anesthesia must be readily produced and reversed on demand [3]. “Soft […]

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Uncategorized Published - 27 September, 2022    By - Dr Clemens
10 Ways to Improve Patient Engagement in Pain Treatment Plans

Authors: Cosio D, Demyan A. Pract Pain Manag. 2022 September/October;22(5). Interdisciplinary, biopsychosocial treatments are the gold standard for the self-management of chronic pain. Non-traditional interventions, such as psychological and complementary and integrative health (CIH) approaches, appear to be unequivocally effective and often come with lower risk. Patients, however, often expect traditional interventions, such as pharmacological, […]

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Uncategorized Published - 27 September, 2022    By - Dr Clemens
What medication options exist for migraine prophylaxis when solid oral dosage forms cannot be administered?

Authors: Holshouser B, Ferguson M. Pract Pain Manag. 2022 September/October;22(5). For children and adolescents, the prevalence of migraine by age 15 is 8% to 23%, and around 38.8% of Americans age 12 and older should be offered or considered for preventive migraine treatment. Due to the debilitating nature of migraine disorder, it is important to […]

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Uncategorized Published - 26 September, 2022    By - Dr Clemens
Liposomal Bupivacaine’s Effect on the Diaphragm: Comment

Authors: Luigi Vetrugno, M.D. et al  Anesthesiology September 2022. To the Editor: We read with great interest the article by Berg et al.  about the evaluation of diaphragmatic excursion after interscalene nerve block with liposomal bupivacaine versus plain bupivacaine. In their study, the authors investigated as a primary outcome the effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine […]

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Uncategorized Published - 26 September, 2022    By - Dr Clemens
Dural Puncture Epidural in Obese Parturients: Comment

Authors: Weijia Du, M.D.; Zhiqiang Liu, M.D., Ph.D. Anesthesiology September 2022. To the Editor: We are writing to raise some concerns about the study conducted by Tan et al.  Their article “Quality of Labor Analgesia with Dural Puncture Epidural versus Standard Epidural Technique in Obese Parturients: A Double-blind Randomized Controlled Study” demonstrated that dural puncture epidural did not provide additional […]

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Uncategorized Published - 26 September, 2022    By - Dr Clemens
Dural Puncture Epidural in Obese Parturients: Reply

Authors: Hon Sen Tan, M.D., et al  Anesthesiology Newly Published on September 2022. In Reply: We thank Du and Liu  for their comments regarding our study assessing the quality of labor analgesia with the dural puncture epidural versus the standard epidural technique in obese parturients.  They raise concerns that 6 ml·h of 0.1% ropivacaine with 2 μg·ml fentanyl administered as […]

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Uncategorized Published - 26 September, 2022    By - Dr Clemens
Ketamine Pharmacodynamics Entangled: Comment

Authors: T. Andrew Bowdle, M.D., Ph.D., F.A.S.E. et al  Anesthesiology September 2022. To the Editor: We read with interest the study of ketamine psychedelic and analgesic effects by Olofsen et al.  and the accompanying editorial by Mashour. In both articles, the authors refer to the “dissociative” effects of ketamine. Corssen and Domino3  originally used the term “dissociative” in […]

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Uncategorized Published - 26 September, 2022    By - Dr Clemens
Ketamine Pharmacodynamics Entangled: Reply

Authors: Albert Dahan, M.D., Ph.D. et al  Anesthesiology September 2022 In Reply: We thank Bowdle et al. for their interest in our article  and for the important issue they raise, paraphrased as follows: what is the best anthropocentric description of the “mind-altering” effects of a heterogeneous group of compounds and drugs that act at the brain and cause […]

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Uncategorized Published - 26 September, 2022    By - Dr Clemens
Liposomal Bupivacaine’s Effect on the Diaphragm: Reply

Authors: Aaron A. Berg, D.O. et al  Anesthesiology September 2022. In Reply: We thank Vetrugno et al.  for their relevant comments on our article. As Vetrugno et al. pointed out, the liposomal bupivacaine group started at a higher baseline diaphragmatic excursion than the bupivacaine-alone group. This was an unavoidable consequence of our randomization scheme. The difference between the groups, however, […]

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Uncategorized Published - 23 September, 2022    By - Dr Clemens
“Sedation versus General Anesthesia For Tracheal Intubation In Children With Difficult Airways

Authors: Luis Sequera-Ramos, M.D. et al  Anesthesiology August 2022. Background Sedated and awake tracheal intubation approaches are considered safest in adults with difficult airways, but little is known about the outcomes of sedated intubations in children. The primary aim of our study is to compare the first attempt success rate of tracheal intubation during sedated […]

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