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Uncategorized Published - 6 December, 2022    By - Dr Clemens
Responses to 2 Workforce Questions from Curious Readers

Author: Thomas R. Miller, PhD, MBA ASA Monitor November 2022, Vol. 86, 1–8. I thank the readers who have emailed comments and questions to The Curious Economist. Recently, several curious readers asked two important anesthesia workforce-related questions, and my responses are the topics of this month’s column. The inquiries were: What are the trends in anesthesia […]

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Uncategorized Published - 5 December, 2022    By - Dr Clemens
Perioperative Mortality in Pediatric Patients

Authors: Virginia E. Tangel, M.A., M.Sc et al Anesthesiology November 2022, Vol. 137, 555–567. Background There are multiple preoperative risk scores for pediatric mortality. The aim of this study was to systematically describe and compare the existing studies of patient-specific multispecialty risk prediction scores for perioperative mortality in pediatric populations, with the goal of guiding clinicians […]

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Uncategorized Published - 5 December, 2022    By - Dr Clemens
Prediction of Postoperative Deterioration in Cardiac Surgery Patients Using Electronic Health Record and Physiologic Waveform Data

Authors: Michael R. Mathis, M.D.; et al  Anesthesiology November 2022, Vol. 137, 586–601. Background Postoperative hemodynamic deterioration among cardiac surgical patients can indicate or lead to adverse outcomes. Whereas prediction models for such events using electronic health records or physiologic waveform data are previously described, their combined value remains incompletely defined. The authors hypothesized that models […]

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Uncategorized Published - 5 December, 2022    By - Dr Clemens
Why Pain Physicians Need to Make Room for Acupuncture

Author: Jim King Practical Pain Management Sep 29, 2022 Multimodal, non-Western therapy can help patients with persistent pain, especially when other treatment modalities fail. Drs. Johnathan Goree and Carrie Hyde share their clinical experience. Physicians treating chronic pain have a range of options, but many modalities have a high failure rate and some have serious […]

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Uncategorized Published - 5 December, 2022    By - Dr Clemens
Supreme Court Backs Prescribers in Opioid Case: Future Implications for Pain Clinicians

Justice Department may still pursue cases if they can prove a doctor knowingly or intentionally prescribed controlled substances, including opioids, without evidence of medical necessity. Prescribers should document patient need, treatment plans, and more. Author: Katie Bennett JD Pract Pain Manag. 2022 September/October;22(5). While the recent onslaught of Supreme Court decisions has left our divided […]

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Uncategorized Published - 5 December, 2022    By - Dr Clemens
Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Authors: Helen Hoyt, B.S. et al  Anesthesiology November 2022, Vol. 137, 568–585. Background Etomidate, barbiturates, alfaxalone, and propofol are anesthetics that allosterically modulate γ-aminobutyric acid type A (GABAA) receptors via distinct sets of molecular binding sites. Two-state concerted coagonist models account for anesthetic effects and predict supra-additive interactions between drug pairs acting at distinct sites. Some behavioral and […]

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Uncategorized Published - 2 December, 2022    By - Dr Clemens
Preoperative β-Blocker Therapy and Stroke or Major Adverse Cardiac Events in Major Abdominal Surgery

Authors: Nicholas L. McKenzie, BSPH et al  Anesthesiology  October 2022. Background Perioperative beta-blocker therapy has been associated with increased risk of stroke. However, the association between beta-blocker initiation prior to the day of surgery and the risk of stroke is unknown. We hypothesized there would be no association between preoperative beta-blocker initiation within 60 days […]

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Uncategorized Published - 2 December, 2022    By - Dr Clemens
Opioids: The Elephant in the Room

“Empire of Pain: The Secret History of the Sackler Dynasty” By Radden Keefe Patrick, New York Doubleday 2021 Pages: 560. ISBN 978-0-385-54568-6. Price: $21 (Hardcover); $15.99 (Kindle Edition). “Dopesick: Dealers, Doctors, and the Drug Company that Addicted America” By Macy Beth, New York,  Little Brown and Company, 2018 . Pages: 400. ISBN 978-0-316-55128-1. Price: $29.69 […]

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Uncategorized Published - 2 December, 2022    By - Dr Clemens
CRPS and Non-Conventional Pharmacological Therapies

Authors: Tran D, Ferguson M. Pract Pain Manag. 2022 September/October;22(5). CRPS: A Brief Background Complex regional pain syndrome (CRPS) is a chronic neuro-inflammatory disorder that affects one or more extremities, usually following surgery, injury, or trauma, but also occurs spontaneously. The pathophysiology of CRPS is complex and poorly understood; therefore, well-defined criteria for diagnosis are […]

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Uncategorized Published - 2 December, 2022    By - Dr Clemens
Biased Signaling in G-Protein-Coupled Receptors: The μ Opioid Receptor

Authors: Richard Simoneaux; Steven L. Shafer, MD, FASA ASA Monitor October 2022, Vol. 86, 1–8. In 2012, the Nobel Prize in Chemistry was awarded to Robert J. Lefkowitz, Howard Hughes Medical Institute/Duke University Medical Center, and Brian K. Kobilka, Stanford University School of Medicine, for “groundbreaking discoveries that reveal the inner workings of… G-protein-coupled receptors” (asamonitor.pub/3Cb1vVL). G-protein-coupled […]

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