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Uncategorized Published - 8 March, 2023    By - Dr Clemens
OCP002, a Mixed Agonist of Opioid and Cannabinoid Receptors, Produces Potent Antinociception With Minimized Side Effects 2023

AUTHORS: Xu, Biao PhD et al  Anesthesia & Analgesia 136(2):p 373-386, February 2023. BACKGROUND: Increasing attention has been attracted to the development of bifunctional compounds to minimize the side effects of opioid analgesics. Pharmacological studies have verified the functional interaction between opioid and cannabinoid systems in pain management, suggesting that coactivation of the opioid and cannabinoid […]

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Uncategorized Published - 8 March, 2023    By - Dr Clemens
Effect of Glutamine Administration After Cardiac Surgery on Kidney Damage in Patients at High Risk for Acute Kidney Injury 2023

AUTHORS: Weiss, Raphael MD et al  Anesthesia & Analgesia November 29, 2022. BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with increased morbidity and mortality. However, no specific treatment options are available, emphasizing the need for preventive measures. The aim of this study was to clarify the effect […]

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Uncategorized Published - 8 March, 2023    By - Dr Clemens
Understanding the Intricacies of Delivering Compassionate Care in the Intensive Care Unit and What Hinders It: A Qualitative Study of Members of 2 Critical Care Societies 2023

AUTHORS: Siddiqui, Shahla MD, MSc, FCCM et al  Anesthesia & Analgesia December 01, 2022. BACKGROUND: Patient-centered care is increasing in importance especially in the post-coronavirus disease 2019 (COVID-19) pandemic era. We sought to understand factors affecting compassionate care faced by intensivists in the intensive care unit (ICU). METHODS: Using survey methodology incorporating 3 real-life case vignettes, […]

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Uncategorized Published - 8 March, 2023    By - Dr Clemens
Regional anesthesia global health collaborations- a scoping review of current intervention methods 2023

Authors: Dohlman, Lena E et al  Current Opinion in Anaesthesiology 35(5):p 647-653, October 2022. Purpose of review  Perioperative anesthesia-related mortality is significantly higher in low-resource compared to high-resource countries. Regional anesthesia techniques can provide safety, cost, and access benefits when compared to general anesthesia in these settings but is underutilized primarily due to a lack of […]

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Uncategorized Published - 8 March, 2023    By - Dr Clemens
Usefulness of Inhaled Sedation in Patients With Severe ARDS Due to COVID-19 2023

DG Journal Club AUTHORS: Mario Gómez Duque, Ronald Medina, Cesar Enciso, Edgar Beltran Respir Care. 2022 Nov 22 BACKGROUND Sedation in intensive care is fundamental for optimizing clinical outcomes. For many years the world has been facing high rates of opioid use, and to combat the increasing opioid addiction plans at both national and international […]

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Uncategorized Published - 7 March, 2023    By - Dr Clemens
Association Between the FRAIL Scale and Postoperative Complications in Older Surgical Patients 2023

AUTHORS: Gong, Selena BhSc et al  Anesthesia & Analgesia 136(2):p 251-261, February 2023.  Abstract BACKGROUND: Several frailty screening tools have been shown to predict mortality and complications after surgery. However, these tools were developed for in-person evaluation and cannot be used during virtual assessments before surgery. The FRAIL (fatigue, resistance, ambulation, illness, and loss of weight) […]

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Uncategorized Published - 7 March, 2023    By - Dr Clemens
Optimal Positioning of Nasopharyngeal Temperature Probes in Infants and Children 2023

AUTHORS: Zhong, John W. MD et al  Anesthesia & Analgesia November 29, 2022. BACKGROUND: The nasopharynx is an easily accessible core-temperature monitoring site, but insufficient or excessive nasopharyngeal probe insertion can underestimate core temperature. Our goal was to estimate optimal nasopharyngeal probe insertion depth as a function of age. METHODS: We enrolled 157 pediatric patients […]

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Uncategorized Published - 7 March, 2023    By - Dr Clemens
A Pilot Prospective Observational Study of Cerebral Autoregulation and 12-Month Outcomes in Children With Complex Mild Traumatic Brain Injury 2023

Authors: Thamjamrassri, Thanyalak MD et al  Journal of Neurosurgical Anesthesiology 34(4):p 384-391, October 2022. Background: The relationship between cerebral autoregulation and outcomes in pediatric complex mild traumatic brain injury (TBI) is unknown, and explored in this study. Methods: We conducted a prospective observational study of patients aged 0 to 18 years hospitalized with complex mild TBI […]

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Uncategorized Published - 7 March, 2023    By - Dr Clemens
Achieving Competency in Fiber-Optic Intubation Among Resident Physicians After Higher- Versus Lower-Fidelity Task Training 2023

AUTHORS: Melvin, Martina T. FCAI et al  Anesthesia & Analgesia November 29, 2022. BACKGROUND: The high-fidelity ORSIM (Airway Simulation Ltd) and the low-fidelity wooden-block fiber-optic task trainers allow users to familiarize themselves with the psychomotor skills required to manipulate the fiber-optic scope. METHODS: This single-center study aimed to compare residents’ performance of fiber-optic intubation after […]

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Uncategorized Published - 7 March, 2023    By - Dr Clemens
What to know about the four levels of hospice care 2023

This is for our readers who treat terminal pain patients. Author: Alicia Sparks Akers MedicalNewsToday Hospice care is a multilevel end-of-life care system that aims to manage symptoms and improve the quality of life for someone with a terminal illness. There are four levels of hospice care, each focusing on the specific needs of the […]

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