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Uncategorized Published - 5 January, 2024    By - Dr Clemens
Opioid Induced Respiratory Depression— Beyond Sleep Disordered Breathing

Author: Toby N. Weingarten, MD Anesthesia Patient Safety Foundation Volume 38, No. 2 • June 2023  More than a decade ago the APSF established a clear edict: “No patient should be harmed by opioid-induced respiratory depression in the postoperative period.”1 Research studies established a strong association between obstructive sleep apnea (OSA) and adverse postoperative opioid-related outcomes. In […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
A Pharmacological Evaluation of the Analgesic Effect and Hippocampal Protein Modulation of the Ketamine Metabolite (2R,6R)-Hydroxynorketamine in Murine Pain Models

AUTHORS: Das, Vaskar PhD et al  Anesthesia & Analgesia June 2023. BACKGROUND: The ketamine metabolite (2R,6R)-hydroxynorketamine ([2R,6R]-HNK) has analgesic efficacy in murine models of acute, neuropathic, and chronic pain. The purpose of this study was to evaluate the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) dependence of (2R,6R)-HNK analgesia and protein changes in the hippocampus in murine pain models administered […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Trending Ability of End-Tidal Capnography Monitoring During Mechanical Ventilation to Track Changes in Arterial Partial Pressure of Carbon Dioxide in Critically Ill Patients With Acute Brain Injury

AUTHORS: Coëffic, Adrien MD et al  Anesthesia & Analgesia June 2023. BACKGROUND: Changes in arterial partial pressure of carbon dioxide (Paco2) may alter cerebral perfusion in critically ill patients with acute brain injury. Consequently, international guidelines recommend normocapnia in mechanically ventilated patients with acute brain injury. The measurement of end-tidal capnography (Etco2) allows its approximation. […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Prevalence and Persistence of Prescription Opioid Use Following Hospital Discharge After Childbirth

AUTHORS: Varney, Bianca MIPH et al  Anesthesia & Analgesia June 2023. BACKGROUND: Opioid analgesics are used for acute postpartum pain relief but carry risks, including persistent long-term opioid use. Our primary objective was to estimate the prevalence of persistent use following hospital discharge after childbirth. METHODS: We conducted a population-based cohort study of women discharged […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Is Continuous Intraoperative Monitoring of Mean Arterial Pressure as Good as the Hypotension Prediction Index Algorithm?

Authors: Marijn P. Mulder, M.Sc. et al  Anesthesiology June 2023, Vol. 138, 657–658. To the Editor: The Hypotension Prediction Index is a validated machine learning algorithm based on numerous characteristics of the arterial waveform and aimed at predicting hypotension up to 15 min in advance.  The recent special article by Enevoldsen and Vistisen focused on the data […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Visual Illusion Results in Malfunction of Anesthesia Machine Sensors

Authors: Steven Simon et al  Anesthesia Patient Safety Foundation Volume 38, No. 2 • June 2023  A 57-year-old male underwent a robotic assisted ventral hernia repair under general endotracheal anesthesia. This was the first case of the day and the Avance CS2 (GE Healthcare, Chicago, IL) machine passed the automated check. There was no reported malfunction of […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
New Practice Guidelines for Neuromuscular Blockade

Authors: Connie Chung, MD et al Anesthesia Patient Safety Foundation Volume 38, No. 2 • June 2023  The American Society of Anesthesiologists (ASA) Committee on Practice Parameters (CPP), chaired by Karen Domino, MD, MPH, created a task force to develop guidelines for neuromuscular blockade (NMB) to improve patient safety and satisfaction. The Anesthesia Patient Safety Foundation […]

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Uncategorized Published - 3 January, 2024    By - Dr Clemens
The Effect of Prophylactic Steroids on Shivering in Adults Undergoing Surgery

AUTHORS: Misra, Satyajeet MD, DNB, PDCC, TOE (EACVI) et al  Anesthesia & Analgesia 137(2):p 332-344, August 2023. BACKGROUND: Shivering is common following anesthesia and surgery. Corticosteroids (steroids) have been tried to reduce the risk of shivering, but the evidence in favor of their use is uncertain. The primary objective of this review was to evaluate the […]

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Uncategorized Published - 3 January, 2024    By - Dr Clemens
Association of Obstructive Sleep Apnea With Unanticipated Admission Following Nonotolaryngologic Pediatric Ambulatory Surgery

AUTHORS: Willer, Brittany L. MD et al  Anesthesia & Analgesia June 2023. BACKGROUND: Approximately 2% of ambulatory pediatric surgeries require unanticipated postoperative admission, causing parental dissatisfaction and suboptimal use of hospital resources. Obstructive sleep apnea (OSA) occurs in nearly 8% of children and is known to increase the risk of perioperative adverse events in children […]

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Uncategorized Published - 3 January, 2024    By - Dr Clemens
Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles

AUTHORS: Wong, Felyx PAIN Reports 8(3):p e1071, May/June 2023. Introduction: Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood. Objectives: In this study, we investigated temporal summation of pain (TSP) profiles, pain ratings and secondary […]

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