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Uncategorized Published - 30 January, 2024    By - Dr Clemens
Reversal of propofol-induced depression of the hypoxic ventilatory response by BK-channel blocker ENA-001

Authors: Simone C Jansen, MD et al  Anesthesiology January 2024 Background The use of anesthetics may result in depression of the hypoxic ventilatory response. Since there are no receptor-specific antagonists for most anesthetics, there is the need for agnostic respiratory stimulants, that increase respiratory drive irrespective of its cause. We tested whether ENA-001, an agnostic […]

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Uncategorized Published - 30 January, 2024    By - Dr Clemens
Gastric volume and antral area in the fasting state. A meta-analysis of individual patient data.

Authors: Anahi Perlas, MD, FRCPC et al  Anesthesiology January 2024. Background Pulmonary aspiration of gastric content is a serious anesthetic complication. Gastric point-of-care ultrasound can determine the type and volume of gastric content when clinical information is equivocal. However, a cut-off value of either antral cross-sectional area or volume that may be considered as the […]

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Uncategorized Published - 30 January, 2024    By - Dr Clemens
Antithrombin levels and heparin responsiveness during veno-arterial extracorporeal membrane oxygenation

Authors: Alexandre Mansour et al  Anesthesiology January 2024. Background Unfractionated heparin, administered during veno-arterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depend on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation however its association with acquired antithrombin deficiency is poorly understood. Our objective was to describe longitudinal […]

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Uncategorized Published - 30 January, 2024    By - Dr Clemens
Good news, bad news for physicians in 2024

Author: Patsy Newitt Becker’s ASC Review From noncompete bans to pay cuts, here are three pieces of good news and three pieces of bad news facing physicians in 2024: The good news More states ban noncompetes States have been increasingly changing noncompete laws, which affect between 37% and 45% of physicians, according to a June 13 blog […]

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Uncategorized Published - 30 January, 2024    By - Dr Clemens
Rock n’ Open Brain Surgery

RocaNews A Florida guitarist played rock music while undergoing brain surgery, WSVN Miami reported Christian Nolen, a professional guitarist, was diagnosed with a brain tumor. Doctors scheduled him for an awake craniotomy, a type of surgery in which the patient is kept awake for parts of it During those operations, doctors ask patients to perform tasks […]

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Uncategorized Published - 29 January, 2024    By - Dr Clemens
Celebrating Anesthesiologist Week: The Unsung Heroes of Modern Medicine

  Author: Rob Clemens MD, MBA, PhD Anesthesiologists are often the unsung heroes in the world of healthcare, working tirelessly behind the scenes to ensure that patients receive safe and pain-free surgical and medical procedures. As we celebrate Anesthesiologist Week, it’s time to shine a spotlight on these dedicated medical professionals and recognize the crucial […]

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Uncategorized Published - 29 January, 2024    By - Dr Clemens
Preoperative Renin-Angiotensin System Antagonists Intake and Blood Pressure Responses During Ambulatory Surgical Procedures

AUTHORS: Gurunathan, Usha FANZCA et al  Anesthesia & Analgesia January 18, 2024. BACKGROUND: There is limited evidence to inform the association between the intake of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) and intraoperative blood pressure (BP) changes in an ambulatory surgery population. METHODS: Adult patients who underwent ambulatory surgery and were discharged on […]

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Uncategorized Published - 29 January, 2024    By - Dr Clemens
Tranexamic Acid Administration During Liver Transplantation Is Not Associated With Lower Blood Loss or With Reduced Utilization of Red Blood Cell Transfusion

AUTHORS: Dehne, Sarah MD et al  Anesthesia & Analgesia January 18, 2024. BACKGROUND: Current clinical guidelines recommend antifibrinolytic treatment for liver transplantation to reduce blood loss and transfusion utilization. However, the clinical relevance of fibrinolysis during liver transplantation is questionable, a benefit of tranexamic acid (TXA) in this context is not supported by sufficient evidence, […]

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Uncategorized Published - 29 January, 2024    By - Dr Clemens
Microglia Promote Inhibitory Synapse Phagocytosis in the Spinal Cord Dorsal Horn and Modulate Pain-Like Behaviors in a Murine Cancer-Induced Bone Pain Model

AUTHORS: Zhang, Zuoxia MD, PhD et al  Anesthesia & Analgesia January 19, 2024. BACKGROUND: The microglial activation has been implicated in cancer-induced bone pain. Recent studies have revealed that microglia mediate synaptic pruning in the central nervous system, where the cluster of differentiation 47-signal regulatory protein α (CD47-SIRPα) axis creates a “don’t eat me” signal […]

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Uncategorized Published - 29 January, 2024    By - Dr Clemens
Comparative Gene Signature of Nociceptors Innervating Mouse Molar Teeth, Cranial Meninges, and Cornea

AUTHORS: Sotelo-Hitschfeld, Pamela PhD et al  Anesthesia & Analgesia January 18, 2024. BACKGROUND: The trigeminal ganglion (TG) collects afferent sensory information from various tissues. Recent large-scale RNA sequencing of neurons of the TG and dorsal root ganglion has revealed a variety of functionally distinct neuronal subpopulations, but organ-specific information is lacking. METHODS: To link transcriptomic […]

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