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Uncategorized Published - 30 May, 2024    By - Dr Clemens
Pain during Cesarean Delivery: We Can and Must Do Better

Authors: Mark I. Zakowski, M.D. et al  Anesthesiology June 2024, Vol. 140, 1236–1237. To the Editor: The American Society of Anesthesiologists (ASA; Schaumburg, Illinois) House of Delegates recently approved the “Statement on Pain during Cesarean Delivery” from the Committee on Obstetric Anesthesia advising all practitioners on the pervasive problem of failure to achieve pain-free cesarean delivery. […]

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Uncategorized Published - 30 May, 2024    By - Dr Clemens
Preoperative N-Terminal Pro–B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin T and Outcomes After Major Noncardiac Surgery

Authors: Bingcheng Zhao, MD et al  Anesthesiology May 2024. Background Patients undergoing noncardiac surgery have varying risk of cardiovascular complications. This study evaluated preoperative N-terminal pro–B-type natriuretic peptide and high-sensitivity cardiac troponin T to enhance cardiovascular events prediction for major noncardiac surgery. Methods This prospective cohort study included adult patients with cardiovascular disease or risk factors […]

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Uncategorized Published - 30 May, 2024    By - Dr Clemens
Improving Dantrolene Mobilization in Regions with Limited Availability

Authors: Hong Yu, M.D. et al  Anesthesiology June 2024, Vol. 140, 1201–1202. Figure 1 depicts the user interface of the National Remote Emergency System for Malignant Hyperthermia for dantrolene mobilization in China. In National Remote Emergency System for Malignant Hyperthermia, dantrolene can be mobilized in three steps: (1) calculating the minimum dantrolene vials needed; (2) identifying […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses

Authors: Jeffrey H. Silber, MD, PhD et al Anesthesiology May 2024. Background Observational studies of anesthetic neurotoxicity may be biased because children requiring anesthesia commonly have medical conditions associated with neurobehavioral problems. This study takes advantage of a natural experiment associated with appendicitis, in order to determine if anesthesia and surgery in childhood were specifically […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Novel Resuscitation Strategies in Severe Trauma: Reply

Authors: David J. Douin, M.D.; Ana Fernandez-Bustamante, M.D., Ph.D., FASA. Anesthesiology June 2024, Vol. 140, 1238–1239. In Reply: We are grateful to Drs. Kowalczyk and Farber for their thorough review and insightful response to our recent clinical focused review of the administration of fibrinogen to mitigate endothelial dysfunction after acute traumatic injury. We appreciate their constructive critique regarding […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Novel Resuscitation Strategies in Severe Trauma: Comment

Authors: John J. Kowalczyk, M.D.; Michaela K. Farber, M.D., M.S. Anesthesiology June 2024, Vol. 140, 1237–1238. To the Editor: We read with great interest the review of “Early Fibrinogen Replacement to Treat the Endotheliopathy of Trauma: Novel Resuscitation Strategies in Severe Trauma” by Douin et al.  This article explores endothelial dysfunction that can occur with the coagulopathy of trauma, […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
American Society of Anesthesiologists 2023 Guidance on Neurologic Complications of Neuraxial Analgesia/Anesthesia in Obstetrics

Authors: Manuel C. Vallejo, M.D., D.M.D. et al  Anesthesiology June 2024, Vol. 140, 1235–1236. To the Editor: Both parturients and healthcare providers have fears of neurologic complications associated with neuraxial analgesia/anesthesia, even though the odds are 5- to 10-fold higher for obstetric-related injury. More than half of parturients want to be informed of anesthetic risks even […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Combined Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Surgery of the Foot or Ankle

Authors: Mathias Maagaard, M.D. et al  Anesthesiology June 2024, Vol. 140, 1165–1175. Background Both dexamethasone and dexmedetomidine increase the duration of analgesia of peripheral nerve blocks. The authors hypothesized that combined intravenous dexamethasone and intravenous dexmedetomidine would result in a greater duration of analgesia when compared with intravenous dexamethasone alone and placebo. Methods The authors randomly […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Antithrombin Levels and Heparin Responsiveness during Venoarterial Extracorporeal Membrane Oxygenation

Authors: Alexandre Mansour, M.D., Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1153–1164. Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation; however, its association with acquired antithrombin deficiency is poorly understood. The objective […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Dexmedetomidine Inhibits Paraventricular Corticotropin-releasing Hormone Neurons that Attenuate Acute Stress-induced Anxiety-like Behavior in Mice

Authors: Gaolin Qiu, M.D. et al  Anesthesiology June 2024, Vol. 140, 1134–1152. Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims to explore the role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRHPVN) neurons in mediating the anxiolytic effects of dexmedetomidine. Methods A social […]

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