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Published in Anesthesiology 2015 Jan 122:21 Authors: Clifford L et al. Transfusion-related acute lung injury and transfusion-associated circulatory overload occurred in several percent of transfused patients. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are important causes of morbidity and mortality in transfused patients. Mayo Clinic researchers conducted two retrospective studies to determine […]
Read MorePublished in Ann Emerg Med 2015 Jan 7 Authors: Schaffer JT et al. Intranasal lidocaine has shown promise as a migraine treatment, but a trial of bupivacaine for unselected headaches disappoints. Prior research has shown intranasal lidocaine to be an effective treatment for migraine (NEJM JW Emerg Med Aug 16 1996). Now, investigators report results […]
Read MorePublished in J Pediatr 2014 Dec 165:1230 Authors: Adelgais KM et al. Abdominal tenderness, more than abdominal pain, predicted intra-abdominal injury and need for acute intervention. To evaluate the accuracy of patient-reported abdominal pain and physician-assessed abdominal tenderness for predicting intra-abdominal injuries in children, investigators conducted a planned secondary analysis of patients <18 years of […]
Read MoreOpioids are frequently prescribed to reproductive-aged women in the U.S., raising concerns about fetal exposure in unrecognized or unintended pregnancies, an MMWR article finds. Opioid exposure during pregnancy is potentially associated with increased risks for neonatal abstinence syndrome and birth defects. CDC researchers examined two databases — one of Medicaid recipients and the other of […]
Read MorePublished in Anesthesiology 2015 Jan 122:29 Authors: Pinheiro de Almeida J et al. A hemoglobin level of 9 g/dL was superior to 7 g/dL as a trigger for transfusion. Randomized trials have shown favorable outcomes with a restrictive red-cell transfusion strategy — that is, not transfusing until hemoglobin levels are <7 g/dL in general critical-care […]
Read MoreFood and Drug Administration (US) AUDIENCE: Pharmacy, Case Manager ISSUE: Hospira announced a voluntary recall of ketorolac tromethamine injection, USP in the United States and Singapore due to potential particulate. The presence of particulate has been confirmed through a customer report of visible, floating particulate identified in glass fliptop vials. The particulate was identified as […]
Read MorePublished in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S. Background: Most anesthetics, particularly intravenous agents such as propofol and etomidate, enhance the actions of the neurotransmitter γ-aminobutyric acid (GABA) at the GABA type A receptor. However, there is no agreement as where anesthetics bind […]
Read MorePublished in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Lianyan Huang, Ph.D.; Guang Yang, Ph.D. Background: Recent studies in rodents suggest that repeated and prolonged anesthetic exposure at early stages of development leads to cognitive and behavioral impairments later in life. However, the underlying mechanism remains unknown. In this study, […]
Read MorePublished in The Journal of the American Society of Anesthesiologists in 1 2015. Authors: Jochen D. Muehlschlegel, M.D. et al Danos C. Christodoulou, Ph.D. Background: The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows the authors to examine the whole transcriptional profile of […]
Read MoreAuthors: Ikuomi Mikuni, M.D., Ph.D. et al Published in The Journal of the American Society of Anesthesiologists on 1 2015. Background: The impact of volatile anesthetics on patients with inherited long QT syndrome (LQTS) is not well understood. This is further complicated by the different genotypes underlying LQTS. No studies have reported on the direct […]
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