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Published in Anesthesiology in 03 2015 Authors: Oressia H. Zalucki, B.Sc., B.A. et al Background: Recent evidence suggests that general anesthetics activate endogenous sleep pathways, yet this mechanism cannot explain the entirety of general anesthesia. General anesthetics could disrupt synaptic release processes, as previous work inCaenorhabditis elegans and in vitro cell preparations suggested a role for the soluble NSF attachment […]
Read MoreAuthors: Susan M. Goobie, M.D., F.R.C.P.C. et al Published in Anesthesiology 2 2015. Background: Craniosynostosis surgery is associated with clinically significant postoperative events requiring intensive care unit (ICU) admission. The authors investigate specific variables, which might influence the risk for these events, and thereby make recommendations regarding the need for postoperative ICU admission. Methods: A retrospective review of […]
Read MorePublished in Anesthesiology 2 2015. Authors: Antonio Montes, M.D., Ph.D. et al Background: Chronic postsurgical pain (CPSP) has been linked to many surgical settings. The authors aimed to analyze functional genetic polymorphisms and clinical factors that might identify CPSP risk after inguinal hernia repair, hysterectomy, and thoracotomy. Methods: This prospective multicenter cohort study enrolled 2,929 patients scheduled for […]
Read MoreAuthors: Dylan W. Maixner, B.S. et al Anesthesiology Published on 2 2015 Background: Neuroinflammation and dysfunctional glial glutamate transporters (GTs) in the spinal dorsal horn are implicated in the genesis of neuropathic pain. The authors determined whether adenosine monophosphate–activated protein kinase (AMPK) in the spinal dorsal horn regulates these processes in rodents with neuropathic pain. Methods: Hind paw […]
Read MoreAuthors: Perry JJ et al., BMJ 2015 Feb 18; 350:h568 The combination of a red blood cell count less than 2000 × 10^6/L and no xanthochromia is sufficient to rule out aneurysmal SAH in patients with traumatic lumbar punctures. The diagnosis of subarachnoid hemorrhage (SAH) often requires lumbar puncture (NEJM JW Emerg Med Mar 2013 and Ann Emerg Med 2013; […]
Read MoreThis is for our provider that treat chronic pain patients. Published in J Allergy Clin Immunol Pract 2014 Jul/Aug 2:414 Authors: Aun MV et al. Epinephrine is first-line treatment for drug-induced anaphylaxis, but it is underutilized. Anaphylaxis is a life-threatening hypersensitivity reaction that can be allergic or nonallergic. Allergic causes of drug-induced anaphylaxis generally are IgE mediated […]
Read MorePublished in Br J Anaesth 2014 Jul 25 Authors: Passi Y et al. Similar laryngeal views were achieved with both devices. The straight Miller laryngoscope blade is traditionally recommended for intubation in infants, due to the large size and flexibility of the infant epiglottis. However, the Miller and Macintosh blades have not been systematically compared in young children. […]
Read MorePublished in Anaesthesia 2014 Aug 2 Authors: Ilyas S et al. Better laryngoscopic views with video laryngoscopy do not equal intubation success. Intubating a trauma patient with cervical spine immobilization can be difficult. Prior studies in this population have shown that video laryngoscopy improves laryngoscopic view and reduces intubation difficulty (NEJM JW Emerg Med Mar 14 2008). […]
Read MoreI thought this was interesting for our providers to know. Published in Emerg Med J 2014 Aug 15; 31:649 Authors: Barkan S et al. Compared with oral midazolam alone, midazolam and ketamine achieved a deeper level of sedation and a higher success rate but led to longer emergency department stays. To compare the efficacy of oral […]
Read MorePublished in JAMA 2014 Jul 16; 312:269 Authors: Jørgensen ME et al. Risk for postoperative adverse cardiovascular events was especially high during the first 9 months after stroke. Stroke is a known risk factor for adverse perioperative outcomes in patients undergoing noncardiac surgery. Whether this relation is time dependent is unclear. Researchers in Denmark examined a […]
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