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Spirometry alone isn’t sufficient to rule out lung disease in current and former smokers, according to an observational study in JAMA Internal Medicine. Some 4400 chronic (current or former) smokers with normal spirometry findings, 800 with mild COPD on spirometry, and 100 never-smokers underwent chest computed tomography, a 6-minute walk test, and symptom questionnaires. CT revealed […]
Read MorePublished in Anesthesiology 6/2015 Authors: Anthony T. Machi, MD et al Background: The authors conducted a randomized, controlled, parallel-arm, superiority study to test the hypothesis that a continuous adductor canal block decreases the time to attain four discharge criteria compared with a continuous femoral nerve block after tricompartment knee arthroplasty. Methods: Subjects undergoing tricompartment knee arthroplasty were […]
Read MorePublished in Anesthesiology 6/2015 Authors: Maurice Jove, MD et al Background: Complications with IV patient-controlled analgesia include programming errors, invasive access, and impairment of mobility. This study evaluated an investigational sufentanil sublingual tablet system (SSTS) for the management of pain after knee or hip arthroplasty. Methods: This prospective, randomized, parallel-arm, double-blind study randomized postoperative patients at […]
Read MorePublished in Anesthesiology 6/2015 Authors: Matthew A. Timmins, B.Sc. Background: Malignant hyperthermia (MH) is triggered by reactions to anesthetics. Reports link nonanesthetic-induced MH-like reactions to a variety of disorders. The objective of the authors was to retrospectively investigate the reasons for referrals for MH testing in nonanesthetic cases and assess their phenotype. In addition, the response to […]
Read MorePublished in Anesthesiology 6/2015 Authors: Terri G. Monk, M.D., M.S. et al Background: Although deviations in intraoperative blood pressure are assumed to be associated with postoperative mortality, critical blood pressure thresholds remain undefined. Therefore, the authors estimated the intraoperative thresholds of systolic blood pressure (SBP), mean blood pressure (MAP), and diastolic blood pressure (DBP) associated with […]
Read MorePublished in Int J Pediatr Otorhinolaryngol 2015 Apr;79(4):499-503 Authors; Sun J et al OBJECTIVES: The randomized, double-blinded, placebo-controlled study evaluated the administration of local infiltration of magnesium combined with ropivacaine to reduce pain scores after pediatric adenotonsillectomy. METHODS: Sixty one subjects received 5ml solution contained 0.25% ropivacaine plus 5mg/kg magnesium sulphate (Group M+R), 5ml 0.25% […]
Read MoreCombining morphine and nortriptyline has been found to successfully relieve chronic neuropathic pain in 87% of patients, and significantly better than with either drug alone, according to a study published in the journal Pain. “Chronic pain is an increasingly common problem and can exert disastrous personal, societal, and socio-economic impacts on patients, their families, and […]
Read MoreNeonatal abstinence syndrome (NAS) has historically been associated with illicit drug use among pregnant women. However, a study published in the April issue of the journal Pediatrics showed an increased likelihood of NAS among pregnant women were narcotic pain relievers such as hydrocodone. In addition, the study found that opioid type and duration of exposure […]
Read MorePublished in Anesthesia & Analgesia April 2015 Authors: Subramanyam, Rajeev MBBS, DNB, MNAMS, MD, MS et al v BACKGROUND: Dexmedetomidine (Dex) appears to be very effective as a sole sedative for pediatric imaging when used at high doses, but at an increased risk of transient hypertension, hypotension, and bradycardia. There are no clinical evidence/guidelines to […]
Read MoreAuthors: Roberts E et al., Ann Rheum Dis 2015 Mar 2; In a review of observational studies, acetaminophen was associated with elevated risks for death and other adverse events. Acetaminophen generally is considered to be safer than nonsteroidal anti-inflammatory drugs and other commonly used analgesics, but randomized controlled trial–level data to support this idea are limited. To […]
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