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Authors: Appelboam A et al., Lancet 2015 Aug 24; A simple modification in the Valsalva maneuver dramatically increased its effectiveness. The Valsalva maneuver is recommended first-line treatment for stable patients with supraventricular tachycardia, although it is successful in only a minority of patients. These authors tested whether a modified Valsalva maneuver can improve cardioversion rates. In a […]
Read MoreAnesthesiology 10 2015, Vol.123, 810-819 Authors: Creed M. Stary, MD, PhD et al Background: Isoflurane induces cell death in neurons undergoing synaptogenesis via increased production of pro-brain–derived neurotrophic factor (proBDNF) and activation of postsynaptic p75 neurotrophin receptor (p75NTR). Astrocytes express p75NTR, but their role in neuronal p75NTR-mediated cell death remains unclear. The authors investigated whether astrocytes have the capacity […]
Read MoreAnesthesiology 9 2015, Vol.123, 524-534 Authors: Chris H. Martini MD et al ; Background: A novel multidimensional index of nociception, the nociception level (NoL) index, derived from the nonlinear composite of heart rate (HR), HR variability, amplitude of the photoplethysmogram, skin conductance, fluctuations in skin conductance, and their time derivatives, was used to assess nociception during anesthesia. Methods: Seventy-two […]
Read MoreAnesthesiology 9 2015, Vol.123, 515-523 Authors: Louise Y. Sun MD, PhD, et al Background: Intraoperative hypotension (IOH) may be associated with postoperative acute kidney injury (AKI), but the duration of hypotension for triggering harm is unclear. The authors investigated the association between varying periods of IOH with mean arterial pressure (MAP) less than 55, less than 60, and […]
Read MoreAnesthesiology 9 2015, Vol.123, 507-514 Authors: Eric C. Sun MD, PhD et al Background: Markets for physician services are becoming increasingly concentrated, with many areas being dominated by a few groups. Antitrust authorities are concerned that increasing concentration will lead to inappropriately high payments for physician services from private insurers. The authors examined the association between market concentration […]
Read MoreAnesthesiology 9 2015, Vol.123, 501-503 Authors: Goran Hedenstierna MD PhD Mechanical ventilation may cause harm to the lung, at least if the lung is already hurt as is the case in intensive care. Can it be harmful also when ventilating the “lung-healthy” patient during anesthesia? Probably not during anesthesia alone, as suggested by animal experiments on […]
Read MoreResearchers are developing a tool they hope will quickly identify surgery patients at greatest risk for opioid-induced respiratory depression (OIRD). With this tool, hospital staff will be better equipped to more closely monitor at-risk patients, which should reduce adverse events, increase patient safety, and improve patient satisfaction, said lead author Nicole Humbert, PharmD, Trinity Hospital, […]
Read MoreA noninvasive wearable nerve stimulator improves pain to the point of needing less analgesia in patients with neuropathy, arthritis, and other common forms of chronic pain, a new study shows. “Our data suggest, and this is mimicked anecdotally, that this device works for about eight out of 10 people,” said Shai Gozani, MD, PhD, president […]
Read MoreNew research has suggested that migraine may be associated with irregularities in the metabolism of certain lipids, opening up new avenues for research into possible treatments and biomarkers for the condition. The research, published in the September issue of Neurology, focused on a group of bioactive lipids known as sphingolipids, which are critical components of cell […]
Read MoreFederal health regulators are drawing attention to the risk of infections with medical scopes used to examine breathing passages, following similar problems with scopes used in the stomach and intestines. The Food and Drug Administration issued a notice Thursday to doctors and nurses who use bronchoscopes — flexible tubes with lights used to examine the […]
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