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Epilepsia. 2015 Sep;56(9):1408-14 AUTHORS: Kay L et al OBJECTIVE: To evaluate the tolerability and efficacy of the ictal and immediate postictal application of intranasal midazolam (in-MDZ) in adolescents and adults during video-electroencephalography (EEG) monitoring. METHODS: Medical records of all patients treated with in-MDZ between 2008 and 2014 were reviewed retrospectively. For each single patient, the time […]
Read MorePaediatr Anaesth. 2015 Jul AUTHORS; Zaidi RH et al BACKGROUND: Urethrocutaneous fistula is a well-known complication of hypospadias surgery. A recent prospective study by Kundra et al. (Pediatr Anesth 2012) has suggested that caudal anesthesia may increase the risk of fistula formation. We sought to evaluate this possible association and determine if any other novel factors may […]
Read MoreAnesthesia & Analgesia: August 2015 AUTHORS: Li, Yuwen PhD et al BACKGROUND: The anesthetic propofol is thought to induce rapid hypnotic sedation by potentiating [gamma]-aminobutyric acid receptor (GABAAR) activity. Little is known about the molecular mechanisms of propofol in modulating inhibitory synaptic transmission. We aimed to investigate the role of propofol in modulating surface expression […]
Read MoreA new study suggests that a routine hospital stay can disturb the balance of the microbiome so much that it sets up some older individuals for life-threatening sepsis. Researchers found that older adults are three times more likely to develop sepsis, a systemic catastrophic response to infection, in the first three months after leaving a […]
Read MorePaediatr Anaesth 2015 Oct;25(10):1020-5 AUTHORS: Rosandwr S et al BACKGROUND: Children with attention-deficit hyperactivity disorder (ADHD) may experience pain differently compared to other children, yet the evidence is equivocal regarding whether pain is heightened or dampened. This prospective observational study, therefore, was designed to compare the postoperative pain experiences in children with and without ADHD. METHODS: Children […]
Read MoreAnesthesia & Analgesia: October 2015 – Volume 121 – Issue 4 – p 1001–1010 AUTHORS: Bailey, Kristen M. MSc et al BACKGROUND: The purpose of this study is to compare the effectiveness of a brief preparation intervention for parental presence during induction of anesthesia (PPIA preparation) with a PPIA with standard preparation (PPIA standard). METHODS: […]
Read MoreAnesthesia & Analgesia: October 2015 – Volume 121 – Issue 4 – p 861–867 AUTHORS: Klinger, Rebecca Y. MD, MS et al BACKGROUND: Hypomagnesemia has been associated with an increased risk of postoperative atrial fibrillation (POAF). Although previous studies have suggested a beneficial effect of magnesium (Mg) therapy, almost all of these are limited by […]
Read MoreThe US Food and Drug Administration (FDA) is investigating the “rare but serious” risk for slowed or difficult breathing in children 17 and younger treated with the opioid analgesic tramadol. “This risk may be increased in children treated with tramadol for pain after surgery to remove their tonsils and/or adenoids,” according to a drug safety alert posted […]
Read MorePediatr Emerg Care 2015 Jul 14 AUTHORS: Hopper et al OBJECTIVE: The aim of the study was to explore physician perceptions of the amount of fluid that demonstrates a successful “trial of fluids” (adequate fluid intake) in the emergency department in children who have had insufficient fluid intake at home. METHODS: This is a secondary analysis […]
Read MoreAnesthesiology 2015 Sep;123(3):524-34 AUTHORS: Martini CH et al BACKGROUND: A novel multidimensional index of nociception, the nociception level (NoL) index, derived from the nonlinear composite of heart rate (HR), HR variability, amplitude of the photoplethysmogram, skin conductance, fluctuations in skin conductance, and their time derivatives, was used to assess nociception during anesthesia. METHODS: Seventy-two American Society of […]
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