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Researchers have determined that patients who have not had an opioid prescription within 1 year prior to their procedure are at low risk of developing persistent opioid use after major surgery. The research, published online by JAMA Surgery, showed that of the 39,140 observed patients only 0.4% (~1 in every 225 patients) continued to receive ongoing […]
Read MoreUsing the common pain-relieving medication acetaminophen during pregnancy was associated with increased risk for multiple behavioural problems in children, according to an article published online by JAMA Pediatrics. Acetaminophen is generally considered safe in pregnancy and is used by a many pregnant women for pain and fever. Evie Stergiakouli, PhD, University of Bristol, Bristol, United […]
Read MoreArthur L. Caplan, PhD Hi. I’m Art Caplan from the Division of Medical Ethics and the New York University (NYU) Langone Medical Center. A former student of mine, who is now in medical school, asked me a question that comes up again and again. I have not talked about it here, but I think it […]
Read MoreScientists are testing an experimental drug that’s designed to have the painkilling power of morphine without some of the side effects that can lead to overdose deaths. Initial results in mice with the compound known for now as PZM21 suggest it might be less addictive than morphine and other opiate painkillers and avoid respiratory depression […]
Read MoreAuthors: Hitoshi Sato et al BMC Anesthesiol. 2016;16(47) Background: Compared to conventional tidal volume ventilation, low tidal-volume ventilation reduces mortality in cased of acute respiratory distress syndrome. The aim of the present study is to determine whether low tidal-volume ventilation reduces the production of inflammatory mediators in the lungs and improves physiological status during hepatic […]
Read MoreLearn more about the use of subanesthetic dosages of IV agents in an outpatient headache and chronic pain clinic. By John Claude Krusz, PhD, MD Most pain practitioners now believe that neuroinflammation plays a role in the initiation, maintenance, and exacerbation of the chronic pain process in the nervous system—both centrally and peripherally.1 Microglial cell activation in […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 587–596 AUTHORS: Mirzakhani, Hooman MD, PhD et al BACKGROUND: Neuromuscular blockade is required to control excessive muscle contractions during electroconvulsive therapy (ECT). In a crossover, assessor-blinded, prospective randomized study, we studied the minimum effective dose (MED) of succinylcholine and rocuronium for ECT. […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 570–577 AUTHORS: Fabbro, Michael II DO et al BACKGROUND: The inflated costs and documented deleterious effects of excess perioperative transfusion have led to the investigation of targeted coagulation factor replacement strategies. One particular coagulation factor of interest is factor I (fibrinogen). Hypofibrinogenemia […]
Read MorePreoperative frailty assessments may help predict mortality and functional decline among seniors undergoing cardiac surgical procedures. The results of this systematic review were published online August 23 in the Annals of Internal Medicine. “Despite various ways of measuring frailty, we found strong evidence that it predicts mortality at 6 months or later after major or minimally invasive procedures,” […]
Read MoreAuthors: Lamy A et al., N Engl J Med 2016 Oct 23; Data on outcomes, cost, and quality of life did not differ significantly between the two coronary artery bypass grafting strategies. In the multinational, randomized CORONARY trial, comparing off-pump (beating heart) with on-pump coronary artery bypass grafting (CABG), the primary endpoint did not differ significantly between […]
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