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Uncategorized Published - 23 December, 2016    By - Dr Clemens
Arterial Pressure Variation in Elective Noncardiac Surgery: Identifying Reference Distributions and Modifying Factors

Authors: Michael R. Mathis, M.D. et al      Anesthesiology published on December 8, 2016 Background: Assessment of need for intravascular volume resuscitation remains challenging for anesthesiologists. Dynamic waveform indices, including systolic and pulse pressure variation, are demonstrated as reliable measures of fluid responsiveness for mechanically ventilated patients. Despite widespread use, real-world reference distributions for systolic and pulse […]

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Uncategorized Published - 23 December, 2016    By - Dr Clemens
Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room

Authors: Matthieu Biais, M.D., Ph.D. et al       Anesthesiology published on December 8, 2016. Background: Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Methods: Twenty-eight mechanically ventilated patients with low tidal volume […]

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Uncategorized Published - 23 December, 2016    By - Dr Clemens
Intravenous Amisulpride for the Prevention of Postoperative Nausea and Vomiting: Two Concurrent, Randomized, Double-blind, Placebo-controlled Trials

Authors: Tong J. Gan, M.D. et al      Anesthesiology published on December 8, 2016. Background: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. Methods: Adult inpatients undergoing elective surgery during general anesthesia and having at […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Autism Gene Improves Understanding of Reduced Pain Sensitivity

Individuals with autism spectrum disorders (ASDs) are known to suffer from reduced pain sensitivity. New research suggests this phenomenon can be linked to a specific gene that may represent a critical avenue for future medications designed to treat chronic pain. By Thomas G. Ciccone   Patients with autism spectrum disorders (ASDs) are known to suffer from […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
New Research: Augmented Reality May Relieve Phantom Limb Pain

Interview with Paul F. Pasquina, MD, and Kiran V. Patel, MD Could “driving” a virtual race car around a track help ease the phantom limb pain that many amputees experience? A small study that focused on 14 patients found that moving and visualizing a phantom limb in augmented reality lessened phantom limb pain. The patients […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Study Finds Rising Rates of Children Hospitalized for Opioid Poisonings

Beyond the rising rates of deaths related to opioid use, a new analysis of hospital records shows significantly higher rates also affecting children being hospitalized for opioid poisoning Interview with Julie R. Gaither, PhD, MPH, RN and G. Caleb Alexander, MD, MS As the deadly consequences of opioid abuse in the US remain in the […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy

Authors: Ross A. Davenport, Ph.D. et al   Anesthesiology 1 2017, Vol.126, 115-127. Background: Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates bleeding, but controversy remains over the degree to which inhibition of procoagulant pathways (anticoagulation), fibrinogen loss, and fibrinolysis drive the […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Withholding versus Continuing Angiotensin-converting Enzyme Inhibitors or Angiotensin II Receptor Blockers before Noncardiac Surgery: An Analysis of the Vascular events In noncardiac Surgery patIents

Authors: Pavel S. Roshanov, M.D., M.Sc. et al Anesthesiology 1 2017, Vol.126, 16-27 Background: The effect on cardiovascular outcomes of withholding angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac surgery is unknown. Methods: In this international prospective cohort study, the authors analyzed data from 14,687 patients (including 4,802 angiotensin-converting enzyme inhibitor/angiotensin II receptor […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Extubation Failure in Brain-injured Patients: Risk Factors and Development of a Prediction Score in a Preliminary Prospective Cohort Study

Authors: Thomas Godet, M.D., Ph.D. et al Anesthesiology 1 2017, Vol.126, 104-114. Background: The decision to extubate brain-injured patients with residual impaired consciousness holds a high degree of uncertainty of success. The authors developed a pragmatic clinical score predictive of extubation failure in brain-injured patients. Methods: One hundred and forty brain-injured patients were prospectively included after the first […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury

Authors: Jukka Kortelainen, M.D., Ph.D. et al Anesthesiology 1 2017, Vol.126, 94-103. Background: Slow waves (less than 1 Hz) are the most important electroencephalogram signatures of nonrapid eye movement sleep. While considered to have a substantial importance in, for example, providing conditions for single-cell rest and preventing long-term neural damage, a disturbance in this neurophysiologic phenomenon is […]

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