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Authors: Annalotta Scheinin, M.D. et al Anesthesiology April 2018. Background: Differentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesized that drug- and state-related changes can be separated. Methods: Forty-seven […]
Read MoreThe Society of Hospital Medicine has released a consensus statement on safely using opioids for acute, noncancer pain in hospitalized patients. The statement, which appears in the Journal of Hospital Medicine, includes 16 recommendations for clinicians. Among them: Restrict opioid use to patients who have severe pain, or those with moderate pain that isn’t well controlled with […]
Read MoreAUTHORS: Kim, Min, Kyoung et al Anesthesia & Analgesia: Oct 2017 BACKGROUND: The success of stellate ganglion block (SGB) is traditionally determined on the basis of findings such as Horner’s syndrome, temperature rise in the face, hyperemia of the tympanic membrane, and nasal congestion. However, decreases in vascular resistance and increases in blood flow in the arm […]
Read MoreThe CDC has issued an alert on serious, unexplained bleeding associated with synthetic cannabinoids (e.g., K2, Spice). The agency says that “a working hypothesis is the synthetic cannabinoids were contaminated with brodifacoum,” an anticoagulant used in rat poison. From March 10 through April 5, some 94 people presented to emergency departments with such bleeding (mostly […]
Read MoreI thought this was interesting since many of our readers have trauma patients In children with blunt trauma, emergent use of whole-body computed tomography doesn’t offer a survival advantage over selective CT, suggests a JAMA Pediatrics study. Using a national injury database, U.S. researchers retrospectively identified nearly 43,000 children aged 6 months to 14 years who underwent […]
Read More‘Why Give 2 When 1 Will Do?’ Author: Steven M. Frank, MD As the problems associated with excessive blood utilization have become apparent, many hospitals around the country are turning to blood management programs as the answer, but the optimal ways to reduce unnecessary red blood cell transfusions remain unclear. While focusing on evidence-based, restrictive […]
Read MoreAUTHORS: Sehmbi, Herman et al Anesthesia & Analgesia: Oct 2017 BACKGROUND: Adductor canal block (ACB) has emerged as an effective analgesic regional technique for major knee surgeries in the last decade. Its motor-sparing properties make it particularly attractive for ambulatory knee surgery, but evidence supporting its use in ambulatory arthroscopic knee surgery is conflicting. This systematic review […]
Read MoreAuthors: Desai, Neel et al Anesthesia & Analgesia: Oc 2017 Anemia is common in elective surgery and is an independent risk factor for morbidity and mortality. Historical management of anemia has focused on the use of allogeneic blood transfusion but this in itself is not without risk. It too has been independently associated with morbidity and […]
Read MoreU.S. drug overdosee deaths increased by more than 20% from 2015 to 2016 — from 16.3 to 19.8 per 100,000 people — according to new data published in MMWR. Among the other findings, based on administrative data from 31 states and Washington, D.C.: Opioids accounted for two-thirds of overdose deaths in 2016. The overdose death rate […]
Read MoreToday, transfusion-related acute lung injury (TRALI) is the leading cause of death following a blood transfusion. So far, it has not been treatable, but a researcher at Lund University in Sweden, Rick Kapur, has now discovered that an anti-inflammatory drug cures the disease in mice. For his achievement, he is awarded the International Society of […]
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