Anesthesiology Published - 28 August, 2025 By - Dr Clemens

Effects of Methylprednisolone on Postoperative Quality of Recovery in Patients Undergoing Minimally Invasive Esophagectomy

Author: Zhang, Hong-Wei M.D. Anesthesiology. October 2025. doi:10.1097/ALN.0000000000005695 This multicenter, double-blind randomized clinical trial evaluated whether a single preoperative dose of intravenous methylprednisolone (120 mg) could improve postoperative quality of recovery (QoR) in patients undergoing minimally invasive esophagectomy. A total of 160 patients from Sichuan Provincial People’s Hospital (Chengdu, China) were randomized to receive either […]

Anesthesiology Published - 1 January, 2025 By - Dr Clemens

Prophylactic Phenylephrine Boluses Versus Variable Rate Infusion During Elective Cesarean Delivery Under Spinal Anesthesia

Authors: Mohta M et al. Anesthesia & Analgesia. 141(4):736–739, October 2025. SummaryThis randomized, double-blind trial compared prophylactic phenylephrine administered as titrated boluses versus variable-rate infusion for prevention of postspinal hypotension during elective cesarean delivery under spinal anesthesia. While international consensus guidelines recommend prophylactic phenylephrine infusion, infusion pumps may not be universally available, particularly in resource-limited […]

Anesthesiology Published - 1 January, 2025 By - Dr Clemens

Single Muscle Fibre Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis

Authors: Singh DP et al. Anesthesiology. December 2025. SummaryThis exploratory validation study evaluated a novel diagnostic technique for malignant hyperthermia (MH) susceptibility based on direct measurement of calcium release dynamics in single skeletal muscle fibers. The current gold standard for MH diagnosis, the in-vitro contracture test (IVCT), is invasive, resource-intensive, and limited to specialized centers. […]

Anesthesiology Published - 1 January, 2025 By - Dr Clemens

Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications

Authors: Wachtendorf LJ et al. Anesthesiology. December 2025. SummaryThis large retrospective cohort study examined how the introduction of sugammadex influenced intraoperative rocuronium dosing practices and whether changes in dosing were associated with postoperative respiratory complications. While sugammadex enables rapid and reliable reversal of even deep neuromuscular blockade, concerns have emerged that its availability may encourage […]