Anesthesiology Published - 5 January, 2026 By - Dr Clemens

Mechanical power and the association with postoperative impaired oxygenation and pulmonary complications in orthopedic patients

Authors: Müller-Wirtz LM et al. Journal: Anesthesiology, Accepted December 18, 2025. DOI: 10.1097/ALN.0000000000005906 SummaryThis post hoc analysis of a large cluster factorial randomized trial evaluated whether intraoperative mechanical power—normalized to predicted body weight—is associated with postoperative oxygenation impairment and pulmonary complications in orthopedic surgical patients. Mechanical power integrates multiple ventilatory variables into a single measure […]

Anesthesiology Published - 5 January, 2026 By - Dr Clemens

Frequency and Management of Maternal Peripartum Cardiac Arrest

Authors: Furdyna MJ et al. Journal: Anesthesiology, Accepted December 23, 2025. DOI: 10.1097/ALN.0000000000005905 SummaryThis large multicenter retrospective cohort study evaluated the frequency, causes, management, and outcomes of maternal peripartum cardiac arrest occurring during peri-anesthetic care in the United States. Using the Multicenter Perioperative Outcomes Group database, the investigators analyzed more than 778,000 deliveries across 60 […]

Anesthesiology Published - 5 January, 2026 By - Dr Clemens

Preoperative Hypnosis versus Mindfulness for Reducing Postoperative Symptoms in Breast Surgery

Authors: Reme SE et al. Journal: Anesthesiology, December 8, 2025. DOI: 10.1097/ALN.0000000000005821 SummaryThis randomized clinical trial compared the effects of a brief preoperative hypnosis session versus mindfulness on postoperative symptoms in women undergoing breast cancer surgery. Recognizing that breast surgery is frequently associated with fatigue, emotional distress, pain, and nausea—and that preoperative anxiety can worsen […]

Anesthesiology Published - 5 January, 2026 By - Dr Clemens

The Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures.

Authors: Jung S et al. Journal: Anesthesiology, Accepted December 19, 2025. DOI: 10.1097/ALN.0000000000005910 SummaryThis experimental laboratory study investigated the mechanism by which isoflurane disrupts neuronal calcium homeostasis, providing mechanistic insight into anesthetic-induced neurotoxicity. Using cultured mouse neurons (both wildtype and mitochondrial mutant), the investigators tested whether prolonged intracellular calcium elevation during anesthetic exposure is driven […]

Anesthesiology Published - 5 January, 2026 By - Dr Clemens

Days cash on hand at 50 health systems

Author: Andrew Cass Becker’s Hospital Review As health systems continue to grapple with financial pressures from rising labor and supply costs and reimbursement challenges, days cash on hand remains an important measure of financial stability. Here are the days cash on hand at 50 health systems as of Sept. 30, according to their most recent financial […]

Anesthesiology Published - 2 January, 2026 By - Dr Clemens

Evaluating Large Language Model Performance in Generating Clinically Relevant Intensive Care Unit Discharge Summaries

Authors: Mudumbai SC et al. A & A Practice. 19(9):e02057, September 2025. SummaryThis study evaluated the clinical quality of large language model (LLM)–generated intensive care unit (ICU) discharge summaries compared with traditional physician-authored summaries. ICU discharge summaries are time-intensive and cognitively demanding, requiring accurate synthesis of complex, longitudinal clinical data. The authors examined whether current […]

Anesthesiology Published - 2 January, 2026 By - Dr Clemens

Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications

Authors: Wachtendorf LJ et al. Anesthesiology. December 2025. SummaryThis large retrospective cohort study examined how the introduction of sugammadex influenced intraoperative rocuronium dosing practices and whether changes in dosing were associated with postoperative respiratory complications. While sugammadex enables rapid and reliable reversal of even deep neuromuscular blockade, concerns have emerged that its availability may encourage […]

Anesthesiology Published - 2 January, 2026 By - Dr Clemens

Single Muscle Fibre Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis

Authors: Singh DP et al. Anesthesiology. December 2025. SummaryThis exploratory validation study evaluated a novel diagnostic technique for malignant hyperthermia (MH) susceptibility based on direct measurement of calcium release dynamics in single skeletal muscle fibers. The current gold standard for MH diagnosis, the in-vitro contracture test (IVCT), is invasive, resource-intensive, and limited to specialized centers. […]

Anesthesiology Published - 2 January, 2026 By - Dr Clemens

Prophylactic Phenylephrine Boluses Versus Variable Rate Infusion During Elective Cesarean Delivery Under Spinal Anesthesia

Authors: Mohta M et al. Anesthesia & Analgesia. 141(4):736–739, October 2025. SummaryThis randomized, double-blind trial compared prophylactic phenylephrine administered as titrated boluses versus variable-rate infusion for prevention of postspinal hypotension during elective cesarean delivery under spinal anesthesia. While international consensus guidelines recommend prophylactic phenylephrine infusion, infusion pumps may not be universally available, particularly in resource-limited […]

Anesthesiology Published - 2 January, 2026 By - Dr Clemens

The Brainstem and Pain: New Research, New Understanding

Author: Lisa O’Mary Medscape Dec 2025 When the hair rises on the back of your neck through a process called piloerection or something hurts so much your primitive response prompts you to run away, your body can completely block out pain to deal with the survival scenario at hand. “Beautiful” is the word Luke Henderson, PhD, […]