⭐ Recognized by FeedSpot: #12 Best Anesthesiology Blog Worldwide

Coagulated Cryoprecipitate in an Intravenous Line

AUTHORS: Alexander B. Shulman, M.D. et al  Anesthesiology July 2022. Cryoprecipitate contains fibrinogen, factor VIII, factor XIII, von Willebrand factor, and fibronectin. Cryoprecipitate production involves cold thawing of plasma to create a supraphysiologic concentrate of these cold-insoluble factors. Up to 20% of cryoprecipitate units are discarded during production because of precipitation or clotting, and careful […]

Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling

Authors: Swati Agarwal, Ph.D. et al  Anesthesiology August 2022, Vol. 137, 212–231. Background Inhalational anesthetics are known to disrupt PDZ2 domain–mediated protein–protein interactions of the postsynaptic density (PSD)-95 protein. The aim of this study is to investigate the underlying mechanisms in response to early isoflurane exposure on synaptic PSD-95 PDZ2 domain disruption that altered spine densities […]

We want to wish all of our readers a fun and safe Labor Day

Coffee Is Not a Clear Liquid

Authors: Pandit, Sujit K. MD; Loberg, Katherine W. BS; Pandit, Uma A. MD Anesthesia & Analgesia: November 2000 In Response: We greatly appreciate Dr. Sosis’s interest in our paper (1). This also gives us an opportunity to clarify the prevalent ambiguity about types of “clear” liquid that are allowed 2–3 h before elective surgery. Dr. Sosis […]

Ultrasound-Guided Clavipectoral Fascial Plane Block With Intermediate Cervical Plexus Block for Midshaft Clavicular Surgery

AUTHORS: Zhuo, Qian MD et al  Anesthesia & Analgesia: September 2022 – Volume 135 – Issue 3 – p 633-640 BACKGROUND: Regional anesthesia such as interscalene brachial plexus block (ISBPB) with intermediate cervical plexus block (ICPB) is generally a preferred choice for clavicular surgery. However, various studies have shown that these blocks, especially ISBPB, could cause […]