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Anesthesiology Published - 5 January, 2026    By - Dr Clemens
The Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures.

Authors: Jung S et al. Journal: Anesthesiology, Accepted December 19, 2025. DOI: 10.1097/ALN.0000000000005910 SummaryThis experimental laboratory study investigated the mechanism by which isoflurane disrupts neuronal calcium homeostasis, providing mechanistic insight into anesthetic-induced neurotoxicity. Using cultured mouse neurons (both wildtype and mitochondrial mutant), the investigators tested whether prolonged intracellular calcium elevation during anesthetic exposure is driven […]

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Anesthesiology Published - 5 January, 2026    By - Dr Clemens
Days cash on hand at 50 health systems

Author: Andrew Cass Becker’s Hospital Review As health systems continue to grapple with financial pressures from rising labor and supply costs and reimbursement challenges, days cash on hand remains an important measure of financial stability. Here are the days cash on hand at 50 health systems as of Sept. 30, according to their most recent financial […]

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Anesthesiology Published - 2 January, 2026    By - Dr Clemens
Evaluating Large Language Model Performance in Generating Clinically Relevant Intensive Care Unit Discharge Summaries

Authors: Mudumbai SC et al. A & A Practice. 19(9):e02057, September 2025. SummaryThis study evaluated the clinical quality of large language model (LLM)–generated intensive care unit (ICU) discharge summaries compared with traditional physician-authored summaries. ICU discharge summaries are time-intensive and cognitively demanding, requiring accurate synthesis of complex, longitudinal clinical data. The authors examined whether current […]

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Anesthesiology Published - 2 January, 2026    By - Dr Clemens
Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications

Authors: Wachtendorf LJ et al. Anesthesiology. December 2025. SummaryThis large retrospective cohort study examined how the introduction of sugammadex influenced intraoperative rocuronium dosing practices and whether changes in dosing were associated with postoperative respiratory complications. While sugammadex enables rapid and reliable reversal of even deep neuromuscular blockade, concerns have emerged that its availability may encourage […]

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Anesthesiology Published - 2 January, 2026    By - Dr Clemens
Single Muscle Fibre Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis

Authors: Singh DP et al. Anesthesiology. December 2025. SummaryThis exploratory validation study evaluated a novel diagnostic technique for malignant hyperthermia (MH) susceptibility based on direct measurement of calcium release dynamics in single skeletal muscle fibers. The current gold standard for MH diagnosis, the in-vitro contracture test (IVCT), is invasive, resource-intensive, and limited to specialized centers. […]

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