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Uncategorized Published - 21 December, 2023    By - Dr Clemens
Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord

Authors: Bing Wang, Ph.D. et al  Anesthesiology December 2023. Background Endoplasmic reticulum (ER) stress plays a crucial role in the pathogenesis of neuroinflammation and chronic pain. Herein, we hypothesized that PRKR-like endoplasmic reticulum kinase (PERK) and Inositol-requiring enzyme type 1 (IRE1) regulate Lipocalin-2 (LCN2) and Nod-like receptor family pyrin domain containing 3 (NLRP3) expression in […]

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Uncategorized Published - 20 December, 2023    By - Dr Clemens
Rapid Titration of Intravenous Treprostinil to Treat Severe Pulmonary Arterial Hypertension Postpartum

AUTHORS: Wang, Tengke MD et al  Anesthesia & Analgesia 129(6):p 1607-1612, December 2019. BACKGROUND: Pulmonary hypertension during pregnancy carries high mortality rate. The relatively long-acting, specific pulmonary vasodilator treprostinil has been used to improve survival in these parturients. Slow uptitration is performed in most cases, and rapid titration has not been reported in the postpartum period. […]

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Uncategorized Published - 20 December, 2023    By - Dr Clemens
An Initial Investigation of Diaphragm Neurostimulation in Patients with Acute Respiratory Distress Syndrome

Authors: Mélodie Parfait, MD et al  Anesthesiology December 2023. Background Lung protective ventilation aims at limiting lung stress and strain. By reducing the amount of pressure transmitted by the ventilator into the lungs, diaphragm neurostimulation offers a promising approach to minimize ventilator induced lung injury. This study investigates the physiological effects of diaphragm neurostimulation in […]

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Uncategorized Published - 20 December, 2023    By - Dr Clemens
Lung Ultrasound Score on Postoperative Day One is predictive of the occurrence of Pulmonary Complications After Major Abdominal Surgery

Authors: Jeremy Boussier, M.D., Ph.D. et al  Anesthesiology December 2023. Background Postoperative pulmonary complications following major abdominal surgery are frequent and carry high morbidity and mortality. Early identification of patients at risk of pulmonary complications by lung ultrasound may allow the implementation of preemptive strategies. We hypothesized that lung ultrasound score would be associated with […]

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Uncategorized Published - 20 December, 2023    By - Dr Clemens
Achieving Age-Friendly Health Care in an Outpatient Perioperative Clinic

Authors: Heather Lander, MD et al  ASA Monitor January 2023, Vol. 87, 20–21. According to a recent World Health Organization (WHO) publication, in 2020 the number of people aged 60 years and older outnumbered children younger than 5 years worldwide (asamonitor.pub/3NC2L83). Simultaneous to the rapidly growing older population, their surgical and perioperative needs are also increasing. […]

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