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Uncategorized Published - 3 July, 2023    By - Dr Clemens
Transforaminal versus interlaminar CT-guided lumbar epidural steroid injections

DG Journal Club AUTHORS: Sylvain Bise et al Skeletal Radiol. 2023 Feb 2 OBJECTIVE To compare the efficacy of the transforaminal approach (TFA) versus the interlaminar approach (ILA) for CT-guided epidural steroid injection (CTESI) in the treatment of persistent lumbosacral radicular pain (LRP > 6 weeks) with long-term follow-up. METHODS Patients were prospectively assessed for pain by visual […]

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Uncategorized Published - 3 July, 2023    By - Dr Clemens
Pre-operative anemia and peri-operative transfusion are associated with poor oncologic outcomes in cancers of the esophagus

DG Journal Club AUTHORS: Joseph P Connor et al BMC Cancer. 2023 Jan 28; 23(1): 99 BACKGROUND Both Red Blood Cell (RBC) transfusion and anemia are thought to negatively impact cancer survival. These effects have been reported with mixed findings in cancer of the esophagus. The potential impact of the application of restrictive transfusion strategies […]

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Uncategorized Published - 3 July, 2023    By - Dr Clemens
Enhanced Recovery After Surgery Program and Opioid Consumption in Pulmonary Resection Surgery

AUTHORS: Son, Jongbae MD et al  Anesthesia & Analgesia 136(4):p 719-727, April 2023. BACKGROUND: Pulmonary resection surgery causes severe postoperative pain and usually requires opioid-based analgesia, particularly in the early postoperative period. However, the administration of large amounts of opioids is associated with various adverse events. We hypothesized that patients who underwent pulmonary resection under an […]

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Uncategorized Published - 3 July, 2023    By - Dr Clemens
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain

AUTHORS: Hsieh, Ming-Chun PhD et al  Anesthesia & Analgesia February 08, 2023.  BACKGROUND:  The microtubule-stabilizing drug paclitaxel (PTX) is an important chemotherapeutic agent for cancer treatment and causes peripheral neuropathy as a common side effect that substantially impacts the functional status and quality of life of patients. The mechanistic role for NIMA-related kinase 2 (NEK2) […]

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Uncategorized Published - 3 July, 2023    By - Dr Clemens
γ-Aminobutyric Acid-Ergic Development Contributes to the Enhancement of Electroencephalogram Slow-Delta Oscillations Under Volatile Anesthesia in Neonatal Rats

AUTHORS: Zhang, Mingyue MD et al Anesthesia & Analgesia February 08, 2023. BACKGROUND: General anesthetics (eg, propofol and volatile anesthetics) enhance the slow-delta oscillations of the cortical electroencephalogram (EEG), which partly results from the enhancement of (γ-aminobutyric acid [GABA]) γ-aminobutyric acid-ergic (GABAergic) transmission. There is a GABAergic excitatory-inhibitory shift during postnatal development. Whether general anesthetics […]

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