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Anesthesiology Published - 13 January, 2026    By - Dr Clemens
Cardiac Biomarkers and Risk Stratification in Liver Transplantation for Acute-on-chronic Liver Failure: Refining Current Risk Models for Improved Prediction of Posttransplant Mortality

Authors: Kwon H-M et al. Journal: Anesthesiology, December 2, 2025. DOI: 10.1097/ALN.0000000000005747 SummaryThis retrospective registry-based study evaluated whether incorporating cardiac biomarkers into existing risk models improves prediction of post–liver transplant mortality in patients with acute-on-chronic liver failure (ACLF). Cardiovascular complications are the leading cause of death after liver transplantation in this population, yet commonly used […]

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Anesthesiology Published - 13 January, 2026    By - Dr Clemens
Liposomal Bupivacaine, Plain Bupivacaine, and Saline for Transversus Abdominis Plane Blocks

Authors: Turan A et al. Journal: Anesthesiology, December 1, 2025. DOI: 10.1097/ALN.0000000000005869 SummaryThis multicenter randomized controlled trial (the CLEVELAND Trial) evaluated whether liposomal bupivacaine provides superior or prolonged analgesia compared with plain bupivacaine or saline when used in single-injection, four-quadrant transversus abdominis plane (TAP) blocks for major abdominal surgery. Given widespread use of liposomal bupivacaine […]

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Anesthesiology Published - 13 January, 2026    By - Dr Clemens
Evaluating The Statistical Robustness Of Randomized Controlled Trials Of Spinal Cord Stimulation For Pain Through The Use Of Fragility Index

Authors: Hussain N et al. Journal: Anesthesiology, December 1, 2025. DOI: 10.1097/ALN.0000000000005876 SummaryThis systematic review evaluated the statistical robustness of randomized controlled trials assessing spinal cord stimulation (SCS for chronic pain using the fragility index (FI). While SCS has gained wide adoption based on statistically significant trial outcomes, the fragility index provides a complementary lens […]

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Anesthesiology Published - 13 January, 2026    By - Dr Clemens
The role of the dorsomedial periaqueductal gray glutamatergic neurons in promoting arousal under multiple general anesthetics in mice

Authors: Tong L et al. Journal: Anesthesiology, December 15, 2025. DOI: 10.1097/ALN.0000000000005903 SummaryThis preclinical study investigated the role of glutamatergic neurons in the dorsomedial periaqueductal gray (dmPAG) as a shared neural substrate regulating arousal and emergence across multiple general anesthetics. Although general anesthetics differ in molecular targets, the authors hypothesized that convergent brainstem circuitry may […]

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Anesthesiology Published - 13 January, 2026    By - Dr Clemens
756 hospitals at risk of closure, state by state

Author: Molly Gamble Becker’s Hospital Review Seven hundred fifty-six rural U.S. hospitals are at risk of closure due to financial problems, with more than 40% of those hospitals at immediate risk of closure. The counts are drawn from the Center for Healthcare Quality and Payment Reform’s most recent analysis, based on hospitals’ latest cost reports submitted […]

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